Baruah Uday Krishna, Gowthamarajan Kuppusamy, Vanka Ravisankar, Karri Veera Venkata Satyanarayana Reddy, Selvaraj Kousalya, Jojo Gifty M
a Department of Pharmaceutics , JSS College of Pharmacy, Ootacamund, JSS University , Mysuru , India.
J Drug Target. 2017 Aug;25(7):567-581. doi: 10.1080/1061186X.2017.1291645. Epub 2017 Feb 28.
We reside in an era of technological innovation and advancement despite which infectious diseases like malaria remain to be one of the greatest threats to the humans. Mortality rate caused by malaria disease is a huge concern in the twenty-first century. Multiple drug resistance and nonspecific drug targeting of the most widely used drugs are the main reasons/drawbacks behind the failure in malarial therapy. Dose-related toxicity because of high doses is also a major concern. Therefore, to overcome these problems nano-based drug delivery systems are being developed to facilitate site-specific or target-based drug delivery and hence minimizing the development of resistance progress and dose-dependent toxicity issues. In this review, we discuss about the shortcomings in treating malaria and how nano-based drug delivery systems can help in curtailing the infectious disease malaria.
我们生活在一个技术创新和进步的时代，尽管如此，像疟疾这样的传染病仍然是对人类最大的威胁之一。疟疾导致的死亡率在21世纪是一个巨大的担忧。最广泛使用的药物的多重耐药性和非特异性药物靶向是疟疾治疗失败的主要原因/缺点。高剂量引起的剂量相关毒性也是一个主要问题。因此，为了克服这些问题，正在开发基于纳米的药物递送系统，以促进位点特异性或基于靶点的药物递送，从而最大限度地减少耐药性进展和剂量依赖性毒性问题的发生。在这篇综述中，我们讨论了治疗疟疾的缺点以及基于纳米的药物递送系统如何有助于控制传染病疟疾。
