Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London SW7 2AZ, UK
J Cell Sci. 2019 Apr 30;132(9):jcs229013. doi: 10.1242/jcs.229013.
The field of mechanobiology studies how mechanical properties of the extracellular matrix (ECM), such as stiffness, and other mechanical stimuli regulate cell behaviour. Recent advancements in the field and the development of novel biomaterials and nanofabrication techniques have enabled researchers to recapitulate the mechanical properties of the microenvironment with an increasing degree of complexity on more biologically relevant dimensions and time scales. In this Review, we discuss different strategies to engineer substrates that mimic the mechanical properties of the ECM and outline how these substrates have been applied to gain further insight into the biomechanical interaction between the cell and its microenvironment.
机械生物学研究细胞外基质（ECM）的机械特性（如硬度）以及其他机械刺激如何调节细胞行为。该领域的最新进展以及新型生物材料和纳米制造技术的发展使研究人员能够在更具生物学相关性的维度和时间尺度上，以越来越高的复杂程度再现微环境的机械特性。在这篇综述中，我们讨论了工程化基底以模拟 ECM 机械特性的不同策略，并概述了这些基底如何应用于深入了解细胞与其微环境之间的生物力学相互作用。
