汽车修理工的血压和血脂状况与铅暴露的关系

Blood Pressure and Lipid Profile in Automechanics in Relation to Lead Exposure.

作者信息

Obi-Ezeani Chikaodili Nwando, Dioka Chudi Emmanuel, Meludu Samuel Chukwuemeka, Onuora Ifeoma Joy, Usman Saheed Opeyemi, Onyema-Iloh Obiageli Bridget

机构信息

Department of Chemical Pathology, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria.

Department of Human Biochemistry, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria.

出版信息

Indian J Occup Environ Med. 2019 Jan-Apr;23(1):28-31. doi: 10.4103/ijoem.IJOEM_122_18.

DOI:10.4103/ijoem.IJOEM_122_18

PMID:31040586

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6477941/

Abstract

CONTEXT

Elevated blood pressure and alterations in lipid and lipoproteins play a major role in the development and progression of cardiovascular diseases.

AIM

This study is aimed at determining the blood pressure and lipid profile in automechanics.

SETTINGS AND DESIGN

A total of 120 male subjects between 18 and 55 years of age comprised 60 automechanics and 60 age-matched occupationally unexposed control subjects in Emene, Enugu State, Nigeria.

SUBJECTS AND METHODS

Four milliliters of fasting blood samples was collected from all subjects, 2 mL of blood was dispensed into K-EDTA vacutainer tube for blood lead analysis, while the other 2 mL was dispensed into plain vacutainer tube, allowed to retract, centrifuged, and the serum used for serum lipid profile analysis. Blood pressure was measured using aneroid sphygmomanometer.

STATISTICAL ANALYSIS

Statistical Package for Social Sciences (SPSS) version 21.0 was used for data analysis.

RESULTS

Automechanics had significantly higher values of systolic and diastolic blood pressures compared with the controls. Serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglyceride (TG) were also significantly higher in the automechanics compared with the controls ( < 0.05); serum high-density lipoprotein cholesterol (HDL-C) level, however, did not differ significantly between the two groups ( > 0.05). Blood lead level showed a significant positive correlation ( < 0.05) with systolic and diastolic blood pressures, serum TC, LDL-C, VLDL-C, and TG, with no significant correlation with serum HDL-C ( > 0.05) in the automechanics and no correlation in the controls.

CONCLUSION

The result of this study indicates that blood pressure is elevated and lipid profile altered in automechanics which suggests that these groups of workers are prone to increased risk of developing hypertension and cardiovascular disorders due to occupational exposure to lead.

摘要

背景

血压升高以及脂质和脂蛋白的改变在心血管疾病的发生和发展中起主要作用。

目的

本研究旨在确定汽车修理工的血压和血脂情况。

设置与设计

在尼日利亚埃努古州埃梅内，共有120名年龄在18至55岁之间的男性受试者，其中包括60名汽车修理工和60名年龄匹配的未接触职业危险因素的对照受试者。

受试者与方法

从所有受试者采集4毫升空腹血样，2毫升血液注入含K-EDTA的真空采血管用于血铅分析，另外2毫升注入普通真空采血管，待血液回缩、离心后，血清用于血脂分析。使用无液式血压计测量血压。

统计分析

采用社会科学统计软件包（SPSS）21.0版进行数据分析。

结果

与对照组相比，汽车修理工的收缩压和舒张压值显著更高。与对照组相比，汽车修理工的血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）和甘油三酯（TG）水平也显著更高（P<0.05）；然而，两组之间的血清高密度脂蛋白胆固醇（HDL-C）水平无显著差异（P>0.05）。在汽车修理工中，血铅水平与收缩压和舒张压、血清TC、LDL-C、VLDL-C和TG呈显著正相关（P<0.05），与血清HDL-C无显著相关性（P>0.05），在对照组中则无相关性。