自发性小发作样癫痫大鼠棘波放电与警觉水平之间的关系。
Relationship between spike-wave discharges and vigilance levels in rats with spontaneous petit mal-like epilepsy.
作者信息
Lannes B, Micheletti G, Vergnes M, Marescaux C, Depaulis A, Warter J M
机构信息
Clinique Neurologique, Hôpital Civil, Strasbourg, France.
出版信息
Neurosci Lett. 1988 Nov 22;94(1-2):187-91. doi: 10.1016/0304-3940(88)90293-5.
The relationship between states of vigilance and spike and wave discharges (SWD) was examined during 12 hours in 4 Wistar rats from a strain bred for spontaneous generalized non-convulsant seizures. On the basis of cortical and hippocampal EEG and EMG activity, wakefulness (W), slow wave sleep (SWS) and paradoxical sleep (REM) were distinguished. Of the SWD 86% occurred during quiet W, 14% during the first minutes of SWS. No SWD occurred during active wakefulness and they were exceptional during REM. These results show that the states of quiet W and transitional states favour the SWD in rats with petit mal-like epilepsy, as in human petit mal.
在来自一个为自发性全身性非惊厥性癫痫培育的品系的4只Wistar大鼠中，对12小时内警觉状态与棘慢波放电（SWD）之间的关系进行了研究。根据皮层和海马脑电图及肌电图活动，区分出觉醒（W）、慢波睡眠（SWS）和异相睡眠（REM）。86%的SWD发生在安静觉醒期间，14%发生在SWS的最初几分钟。在主动觉醒期间未出现SWD，在REM期间也很少出现。这些结果表明，安静觉醒状态和过渡状态有利于失神样癫痫大鼠出现SWD，这与人类失神发作情况相同。
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