Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Environ Health Prev Med. 2020 Aug 29;25(1):44. doi: 10.1186/s12199-020-00886-1.
Petrol is the non-specific term for petroleum which is used for inside combustion of engines. Petrol filling workers are highly vulnerable to occupational exposure to these harmful substances which lead to hemato-toxicity and blood disorders such as leukemia, aplastic anemia, and dysplastic bone marrow. Thus, this study was aimed to assess hematological parameters of petrol filling workers in Gondar town, Northwest Ethiopia.
A comparative cross-sectional study was conducted from January to March 2019 in Gondar town, Northwest Ethiopia. A total of 110 study participants comprising 55 study groups and 55 controls group were recruited by a convenient sampling technique. Socio-demographic data were collected using a structured questionnaire, and 3 ml of venous blood was collected for the determination of hematological parameters. The data were entered into Epi info 7.2.0.1 and analyzed by SPSS version of 20. Mean, standard deviation, median, and interquartile ranges were used to present the data. Independent t test and Mann-Whitney U test were used to compare the mean or median difference between parametric and non-parametric hematological parameters, respectively. Moreover, Pearson product-moment and Spearman's rank-order bivariable correlations analyses were used to describe the correlation between hematological parameters and duration of exposure to petrol. A P value of ≤ 0.05 was considered statistically significant.
The study revealed that mean red blood cell count and hemoglobin level as well as the median hematocrit, mean cell hemoglobin concentration, platelet count, absolute lymphocytes count, and red cell distribution width values of petrol filling workers showed a significant increment compared with the control group. On the other hand, the mean cell hemoglobin value of petrol filling workers showed a significant decrement compared with healthy controls. Moreover, the duration of exposure to petrol showed a significant positive correlation with red blood cell count and mean cell hemoglobin concentration; however, a significant negative correlation was observed with mean cell volume.
This study showed that the majority of hematological parameters of petrol filling workers showed an increment compared with healthy controls which might be associated with exposure to petrol chemicals. However, further longitudinal study with a larger sample size should be conducted to explore the impact of petrol exposure on hematopoiesis.
汽油是用于发动机内部燃烧的石油的非特定术语。加油工人极易接触到这些有害物质，从而导致血液毒性和血液疾病，如白血病、再生障碍性贫血和骨髓发育不良。因此，本研究旨在评估埃塞俄比亚西北部贡德尔镇加油工人的血液学参数。
这是一项 2019 年 1 月至 3 月在埃塞俄比亚西北部贡德尔镇进行的比较性横断面研究。采用便利抽样技术，共招募了 110 名研究对象，包括 55 名研究组和 55 名对照组。使用结构化问卷收集社会人口统计学数据，并采集 3ml 静脉血用于血液学参数的测定。数据输入 Epi info 7.2.0.1 并由 SPSS 版本 20 进行分析。采用均值、标准差、中位数和四分位数间距来表示数据。采用独立 t 检验和曼-惠特尼 U 检验分别比较参数和非参数血液学参数的均值或中位数差异。此外，还采用皮尔逊积矩和斯皮尔曼等级相关双变量分析来描述血液学参数与接触汽油时间之间的相关性。P 值≤0.05 为有统计学意义。
研究表明，与对照组相比，加油工人的平均红细胞计数和血红蛋白水平以及中位数红细胞压积、平均细胞血红蛋白浓度、血小板计数、绝对淋巴细胞计数和红细胞分布宽度值均显著升高。另一方面，加油工人的平均细胞血红蛋白值与健康对照组相比显著降低。此外，接触汽油的时间与红细胞计数和平均细胞血红蛋白浓度呈显著正相关，而与平均细胞体积呈显著负相关。
本研究表明，与健康对照组相比，加油工人的大多数血液学参数均升高，这可能与接触汽油化学物质有关。然而，应该进行进一步的、样本量更大的纵向研究，以探索汽油暴露对造血的影响。
