• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect.

作者信息

Heifets Boris D, Williams Nolan R, Bentzley Brandon S, Schatzberg Alan F

机构信息

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.

出版信息

JAMA Psychiatry. 2019 Jun 1;76(6):657-658. doi: 10.1001/jamapsychiatry.2019.0766.

DOI:10.1001/jamapsychiatry.2019.0766
PMID:31042274
Abstract
摘要

相似文献

1
Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect.严谨的试验设计对于理解阿片受体在氯胺酮抗抑郁作用中的作用至关重要。
JAMA Psychiatry. 2019 Jun 1;76(6):657-658. doi: 10.1001/jamapsychiatry.2019.0766.
2
Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect-Reply.严谨的试验设计对于理解阿片受体在氯胺酮抗抑郁作用中的作用至关重要——回复
JAMA Psychiatry. 2019 Jun 1;76(6):658-659. doi: 10.1001/jamapsychiatry.2019.0763.
3
Rigorous Translational Models Are Key to Studying Ketamine's Antidepressant Mechanism: Response to Wang and Kaplin.严谨的转化模型是研究氯胺酮抗抑郁机制的关键:对王和卡普林的回应。
Am J Psychiatry. 2019 May 1;176(5):412. doi: 10.1176/appi.ajp.2019.19010044r.
4
Explaining Naltrexone's Interference With Ketamine's Antidepressant Effect.解释纳曲酮对氯胺酮抗抑郁作用的干扰。
Am J Psychiatry. 2019 May 1;176(5):410-411. doi: 10.1176/appi.ajp.2019.19010044.
5
Interpreting Ketamine's Opioid Receptor Dependent Effect: Response to Sanacora.解读氯胺酮的阿片受体依赖性效应:对萨纳科拉的回应。
Am J Psychiatry. 2019 Mar 1;176(3):249-250. doi: 10.1176/appi.ajp.2018.18091061r.
6
Ketamine's rapid antisuicidal effects are not attenuated by Buprenorphine.氯胺酮的快速抗自杀作用不会被丁丙诺啡减弱。
J Affect Disord. 2021 Mar 1;282:252-254. doi: 10.1016/j.jad.2020.12.120. Epub 2020 Dec 29.
7
What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities.氯胺酮快速起效的抗抑郁作用机制是什么?对大量惊人可能性的简要概述。
J Clin Pharm Ther. 2017 Apr;42(2):147-154. doi: 10.1111/jcpt.12497. Epub 2017 Jan 22.
8
Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review.5-羟色胺能信号系统在氯胺酮抗抑郁作用中的潜在作用:一项批判性评价。
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:27-38. doi: 10.1016/j.pnpbp.2016.05.007. Epub 2016 Jun 2.
9
Mechanisms of ketamine action as an antidepressant.氯胺酮作为抗抑郁药的作用机制。
Mol Psychiatry. 2018 Apr;23(4):801-811. doi: 10.1038/mp.2017.255. Epub 2018 Mar 13.
10
The endogenous opioid system in the medial prefrontal cortex mediates ketamine's antidepressant-like actions.内侧前额叶皮质中的内源性阿片系统介导了氯胺酮的抗抑郁作用。
Transl Psychiatry. 2024 Feb 12;14(1):90. doi: 10.1038/s41398-024-02796-0.

引用本文的文献

1
Antidepressant efficacy of ketamine plus naltrexone for major depression comorbid with alcohol use disorder: a randomized controlled trial.氯胺酮联合纳曲酮治疗合并酒精使用障碍的重度抑郁症的抗抑郁疗效:一项随机对照试验。
Int J Neuropsychopharmacol. 2025 Aug 1;28(8). doi: 10.1093/ijnp/pyaf056.
2
Ketamine Evokes Acute Behavioral Effects Via μ Opioid Receptor-Expressing Neurons of the Central Amygdala.氯胺酮通过中央杏仁核中表达μ阿片受体的神经元诱发急性行为效应。
Biol Psychiatry. 2025 May 5. doi: 10.1016/j.biopsych.2025.04.020.
3
Improvement in pain by using lidocaine combined with esketamine in elderly patients receiving local anaesthesia for percutaneous kyphoplasty: a randomized controlled study.
利多卡因联合 Esketamine 用于接受经皮椎体后凸成形术局部麻醉的老年患者的疼痛改善:一项随机对照研究。
BMC Anesthesiol. 2024 Oct 23;24(1):384. doi: 10.1186/s12871-024-02768-3.
4
Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials.高期望:改善迷幻药临床试验方法严谨性的建议。
Psychopharmacology (Berl). 2022 Jun;239(6):1989-2010. doi: 10.1007/s00213-022-06123-7. Epub 2022 Apr 1.
5
Activity-State Dependent Reversal of Ketamine-Induced Resting State EEG Effects by Clozapine and Naltrexone in the Freely Moving Rat.氯氮平和纳曲酮对自由活动大鼠氯胺酮诱导的静息态脑电图效应的活动状态依赖性逆转
Front Psychiatry. 2022 Jan 27;13:737295. doi: 10.3389/fpsyt.2022.737295. eCollection 2022.
6
Mechanisms of ketamine and its metabolites as antidepressants.氯胺酮及其代谢物作为抗抑郁药的作用机制。
Biochem Pharmacol. 2022 Mar;197:114892. doi: 10.1016/j.bcp.2021.114892. Epub 2021 Dec 27.
7
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability.氯胺酮对映异构体的药理学和行为学差异:对滥用倾向的影响。
Mol Psychiatry. 2021 Nov;26(11):6704-6722. doi: 10.1038/s41380-021-01093-2. Epub 2021 Apr 15.
8
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.总结氯胺酮和艾司氯胺酮治疗难治性抑郁症的证据:现有证据和实施情况的国际专家意见。
Am J Psychiatry. 2021 May 1;178(5):383-399. doi: 10.1176/appi.ajp.2020.20081251. Epub 2021 Mar 17.
9
Ketamine: A tale of two enantiomers.氯胺酮:对映异构体的两面性。
J Psychopharmacol. 2021 Feb;35(2):109-123. doi: 10.1177/0269881120959644. Epub 2020 Nov 6.
10
Opioid Receptor μ-1 and Ketamine Effects in a Suicidal Depression Trial: A Post Hoc Exploration.阿片受体μ-1与氯胺酮在自杀性抑郁症试验中的作用:一项事后探索
J Clin Psychopharmacol. 2020 Jul/Aug;40(4):420-422. doi: 10.1097/JCP.0000000000001237.