依诺沙星与其他八种抗生素联合对铜绿假单胞菌、肠杆菌科细菌及金黄色葡萄球菌的体外抗菌活性。

In-vitro antimicrobial activity of enoxacin in combination with eight other antibiotics against Pseudomonas aeruginosa, Enterobacteriaceae and Staphylococcus aureus.

作者信息

Baltch A L, Bassey C, Fanciullo G, Smith R P

出版信息

J Antimicrob Chemother. 1987 Jan;19(1):45-8. doi: 10.1093/jac/19.1.45.

DOI:10.1093/jac/19.1.45

Abstract

Susceptibilities of 28 strains of Pseudomonas aeruginosa, 32 strains of Enterobacteriaceae and 24 strains of Staphylococcus aureus were tested against combinations of enoxacin with either cefsulodin, piperacillin, or amikacin, enoxacin with either aztreonam, latamoxef or amikacin, and enoxacin with either oxacillin, clindamycin or vancomycin, respectively. Synergy was detected by the agar dilution technique and was defined as a four-fold decrease in the inhibitory concentration of both drugs (sigma FIC less than or equal to 0.5). Against Ps. aeruginosa, synergy occurred in 28.5% of the strains for enoxacin plus cefsulodin, 17.6% for enoxacin plus piperacillin, and 3.7% for enoxacin plus amikacin. Against the Enterobacteriaceae, synergy was detected with enoxacin plus aztreonam, latamoxef or amikacin in 9.3%, 3.1% and 0% of strains, respectively. Against Staph. aureus, no synergy was demonstrable with enoxacin plus oxacillin, clindamycin or vancomycin. No antagonism was detected for any combination tested. Selected strains demonstrating synergy by the agar dilution method for enoxacin plus cefsulodin or piperacillin failed to show synergy in kinetic studies.

摘要

分别测试了28株铜绿假单胞菌、32株肠杆菌科细菌和24株金黄色葡萄球菌对依诺沙星与头孢磺啶、哌拉西林或丁胺卡那霉素联合用药，依诺沙星与氨曲南、拉氧头孢或丁胺卡那霉素联合用药，以及依诺沙星与苯唑西林、克林霉素或万古霉素联合用药的敏感性。采用琼脂稀释法检测协同作用，其定义为两种药物的抑菌浓度均降低四倍（FIC指数之和小于或等于0.5）。对于铜绿假单胞菌，依诺沙星加头孢磺啶的菌株中28.5%出现协同作用，依诺沙星加哌拉西林的为17.6%，依诺沙星加丁胺卡那霉素的为3.7%。对于肠杆菌科细菌，依诺沙星加氨曲南、拉氧头孢或丁胺卡那霉素的菌株中，分别有9.3%、3.1%和0%检测到协同作用。对于金黄色葡萄球菌，依诺沙星加苯唑西林、克林霉素或万古霉素未显示出协同作用。对于所测试的任何组合均未检测到拮抗作用。通过琼脂稀释法显示依诺沙星加头孢磺啶或哌拉西林有协同作用的选定菌株在动力学研究中未显示出协同作用。