Henwood J M, Monk J P
ADIS Drug Information Services, Manchester, England.
Drugs. 1988 Jul;36(1):32-66. doi: 10.2165/00003495-198836010-00004.
Enoxacin is a new addition to the class of 4-quinolone antibacterial drugs. It has a broad spectrum of in vitro antibacterial activity, and is particularly potent against Gram-negative organisms and staphylococci. The pharmacokinetic profile of enoxacin is similar to that of ofloxacin, achieving higher plasma and tissue concentrations and possessing a longer half-life than norfloxacin or ciprofloxacin. In comparative studies, clinical and/or bacteriological efficacy was comparable or (in studies which statistically analysed the results) not significantly different between enoxacin and amoxycillin in acute cystitis, acute Gram-negative exacerbations of chronic bronchitis and acute or chronic otitis media, between enoxacin and cephalexin in skin, skin structure and soft tissue infections, between enoxacin and trimethoprim in acute cystitis, between enoxacin and co-trimoxazole in complicated urinary tract infection and between enoxacin and pipemidic acid in suppurative otitis media. Significantly (p less than 0.01) more clinical and/or bacteriological cures were effected by enoxacin than pipemidic acid in acute cystitis and complicated urinary tract infection. In uncomplicated gonococcal infections single oral doses of enoxacin were effective in over 90% of patients. Enoxacin is a well-tolerated, orally active broad spectrum antibacterial drug which should prove a worthwhile alternative to currently available antibacterial therapy.
依诺沙星是4-喹诺酮类抗菌药物中的新成员。它具有广泛的体外抗菌活性，对革兰氏阴性菌和葡萄球菌尤其有效。依诺沙星的药代动力学特征与氧氟沙星相似，血浆和组织浓度更高，半衰期比诺氟沙星或环丙沙星更长。在比较研究中，在急性膀胱炎、慢性支气管炎急性革兰氏阴性菌加重以及急性或慢性中耳炎方面，依诺沙星与阿莫西林的临床和/或细菌学疗效相当或（在对结果进行统计分析的研究中）无显著差异；在皮肤、皮肤结构和软组织感染方面，依诺沙星与头孢氨苄相当；在急性膀胱炎方面，依诺沙星与甲氧苄啶相当；在复杂性尿路感染方面，依诺沙星与复方新诺明相当；在化脓性中耳炎方面，依诺沙星与吡哌酸相当。在急性膀胱炎和复杂性尿路感染中，依诺沙星实现的临床和/或细菌学治愈显著（p小于0.01）多于吡哌酸。在单纯性淋菌感染中，单次口服依诺沙星对超过90%的患者有效。依诺沙星是一种耐受性良好、口服有效的广谱抗菌药物，应该会被证明是现有抗菌治疗的一个有价值的替代药物。
