依诺沙星与诺氟沙星及阿米卡星的体外活性比较。

In vitro activity of enoxacin compared with norfloxacin and amikacin.

作者信息

van der Auwera P, de Moor G, Lacroix G, Mambour A, Rossion N, Schuyteneer F

出版信息

Eur J Clin Microbiol. 1985 Feb;4(1):55-8. doi: 10.1007/BF02148662.

Abstract

The in vitro activity of enoxacin was tested against 1000 clinical isolates of gram-positive and gram-negative microorganisms and compared with that of norfloxacin and amikacin. The MIC90 of enoxacin was 1 mg/l for Enterobacteriaceae, 2.6 mg/l for Pseudomonas aeruginosa and 6.2 mg/l or Staphylococcus aureus. The inoculum effect was minimal. The MICs and MBCs for Pseudomonas aeruginosa strains were significantly affected by the addition of calcium and magnesium ions. Synergy was occasionally observed between enoxacin and the antibiotics tested; antagonism was rare.

摘要

对1000株革兰氏阳性和革兰氏阴性微生物临床分离株测试了依诺沙星的体外活性，并与诺氟沙星和阿米卡星进行了比较。依诺沙星对肠杆菌科细菌的MIC90为1mg/L，对铜绿假单胞菌为2.6mg/L，对金黄色葡萄球菌为6.2mg/L。接种物效应极小。添加钙和镁离子会显著影响铜绿假单胞菌菌株的MIC和MBC。依诺沙星与所测试的抗生素之间偶尔会观察到协同作用；拮抗作用很少见。