Bender P R, Weil J V, Reeves J T, Moore L G
J Appl Physiol (1985). 1987 Feb;62(2):640-5. doi: 10.1152/jappl.1987.62.2.640.
The relative contributions of breathing frequency and tidal volume to the increase in ventilation during acute or prolonged exposure to hypoxia is uncertain. We examined the changes in breathing pattern during hypoxic exposures lasting minutes, hours, and days using data from previous studies. Increased tidal volume accounted for the increased ventilation during 7-10 and 30 min of isocapnic and poikilocapnic (no CO2 added) hypoxic exposures as well as during 7 h of poikilocapnic hypobaric hypoxia (4,800 m). Tidal volume was also a greater overall contributor than frequency to increased ventilation in sea-level residents during 3 days of isocapnic hypobaric hypoxia (4,100-4,600 m) and in Denver (1,600 m) residents during 5 days on Pikes Peak (4,300 m). In sea-level residents during 3 days of poikilocapnic hypobaric hypoxia (3,600-4,300 m) and during 7-8 days on Pikes Peak, increased frequency accounted for the rise in ventilation. Tidal volume thus contributed more than frequency to increasing ventilation during brief hypoxia, whereas the contribution of frequency was increased in prolonged hypoxia involving a 4,300-m altitude ascent and hypocapnia.
在急性或长期暴露于低氧环境时，呼吸频率和潮气量对通气增加的相对贡献尚不确定。我们利用先前研究的数据，研究了在持续数分钟、数小时和数天的低氧暴露期间呼吸模式的变化。在等碳酸血症和变碳酸血症（未添加二氧化碳）的低氧暴露7 - 10分钟和30分钟期间，以及在变碳酸血症的低压低氧（4800米）暴露7小时期间，潮气量增加导致通气增加。在海平面居民进行3天的等碳酸血症低压低氧（4100 - 4600米）期间以及丹佛（1600米）居民在派克斯峰（4300米）停留5天期间，潮气量对通气增加的总体贡献也大于频率。在海平面居民进行3天的变碳酸血症低压低氧（3600 - 4300米）期间以及在派克斯峰停留7 - 8天期间，频率增加导致通气增加。因此，在短暂低氧期间，潮气量对通气增加的贡献大于频率，而在涉及海拔4300米上升和低碳酸血症的长期低氧期间，频率的贡献增加。
