Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
State University of New York at Buffalo, Buffalo, New York.
Cancer Epidemiol Biomarkers Prev. 2019 Jul;28(7):1103-1116. doi: 10.1158/1055-9965.EPI-18-1214. Epub 2019 May 1.
Many studies have demonstrated that smoking can influence ovarian cancer risk and survival; however, the number of studies investigating this relationship according to histologic subtypes is limited. We conducted a review of epidemiologic research that assessed the role of smoking on ovarian cancer risk and survival after diagnosis, specifically capturing studies that discerned between various histologic subtypes of this disease. In the majority of studies, current smoking was associated with increased risk of mucinous cancer. There was also evidence of a decreased risk of clear cell and endometrioid histotypes. No significant association was observed between cigarette smoking and serous cancer. In the studies investigating the relationship between smoking and survival, all the studies reported an increased risk of mortality associated with smoking. Smoking appeared to be a risk factor for both ovarian cancer risk and mortality. Future studies need to investigate further a potential link between smoking and ovarian cancer by having a better assessment of exposure to smoking and having a larger number of participants with the ability to detect associations within rare histotypes.
许多研究表明，吸烟会影响卵巢癌的风险和生存率；然而，根据组织学亚型研究这种关系的研究数量有限。我们对评估吸烟对卵巢癌风险和诊断后生存率影响的流行病学研究进行了综述，特别注意区分这种疾病的各种组织学亚型的研究。在大多数研究中，当前吸烟与黏液性癌风险增加有关。也有证据表明透明细胞和子宫内膜样组织类型的风险降低。吸烟与浆液性癌之间没有显著关联。在研究吸烟与生存率之间的关系的研究中，所有研究都报告了与吸烟相关的死亡率风险增加。吸烟似乎是卵巢癌风险和死亡率的一个危险因素。未来的研究需要通过更好地评估吸烟暴露情况和增加有能力检测罕见组织类型中关联的参与者数量，进一步调查吸烟与卵巢癌之间的潜在联系。
