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肌肉生长抑制素基因启动子：结构、保守性及其作为肌肉调节靶点的重要性

Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation.

作者信息

Grade Carla Vermeulen Carvalho, Mantovani Carolina Stefano, Alvares Lúcia Elvira

机构信息

1Universidade Federal da Integração Latino-Americana, UNILA, Instituto Latino-Americano de Ciências da Vida e da Natureza, Avenida Tarquínio Joslin dos Santos, 1000, Foz do Iguaçu, PR CEP 85870-901 Brazil.

2Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas - UNICAMP, Rua Monteiro Lobato, 255, Campinas, SP CEP 13083-862 Brazil.

出版信息

J Anim Sci Biotechnol. 2019 Apr 23;10:32. doi: 10.1186/s40104-019-0338-5. eCollection 2019.

DOI:10.1186/s40104-019-0338-5
PMID:31044074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6477727/
Abstract

Myostatin (MSTN) is one of the key factors regulating myogenesis. Because of its role as a negative regulator of muscle mass deposition, much interest has been given to its protein and, in recent years, several studies have analysed gene regulation. This review discusses the gene promoter, focusing on its structure in several animal species, both vertebrate and invertebrate. We report the important binding sites considering their degree of phylogenetic conservation and roles they play in the promoter activity. Finally, we discuss recent studies focusing on gene regulation via promoter manipulation and the potential applications they have both in medicine and agriculture.

摘要

肌肉生长抑制素（MSTN）是调节肌生成的关键因素之一。由于其作为肌肉质量沉积的负调节因子的作用，人们对其蛋白质给予了极大关注，近年来，多项研究分析了基因调控。本综述讨论了该基因启动子，重点关注其在几种脊椎动物和无脊椎动物物种中的结构。我们报告了重要的结合位点，并考虑了它们的系统发育保守程度及其在启动子活性中所起的作用。最后，我们讨论了最近通过启动子操纵来研究基因调控的研究以及它们在医学和农业中的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/1b5011912dcc/40104_2019_338_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/a3c40b58e4ec/40104_2019_338_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/66c4faf54339/40104_2019_338_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/435dc9942502/40104_2019_338_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/1b5011912dcc/40104_2019_338_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/a3c40b58e4ec/40104_2019_338_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/66c4faf54339/40104_2019_338_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/435dc9942502/40104_2019_338_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2d8/6477727/1b5011912dcc/40104_2019_338_Fig4_HTML.jpg

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Genetic Variations of and in Tibetan Sheep: Implications for Early Growth Traits.藏羊 和 基因变异：对早期生长性状的影响。
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