Kruglikov Ilja L, Scherer Philipp E
Scientific Department, Wellcomet GmbH, Karlsruhe, D-76129 Germany.
2Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-8549 USA.
NPJ Regen Med. 2019 Apr 26;4:9. doi: 10.1038/s41536-019-0071-x. eCollection 2019.
Reduced expression of caveolin-1 (Cav-1) is an important pathogenic factor in hypertrophic scarring (HTS). Such a reduction can be found in connection with the main known risk factors for HTS, including dark skin, female gender, young age, burn site and severity of the injury. The degree of overexpression of Cav-1 associated with different therapeutic options for HTS correlates with clinical improvements in HTS. This makes endo- or exogenous induction of Cav-1 not only an important therapeutic target for HTS, but also highlights its use as a preventive target to reduce or avoid HTS formation.
小窝蛋白-1（Cav-1）表达降低是肥厚性瘢痕形成（HTS）的一个重要致病因素。这种降低与HTS的主要已知危险因素有关，包括深色皮肤、女性、年轻、烧伤部位和损伤严重程度。与HTS不同治疗选择相关的Cav-1过表达程度与HTS的临床改善相关。这使得内源性或外源性诱导Cav-1不仅成为HTS的一个重要治疗靶点，也突出了其作为预防靶点以减少或避免HTS形成的用途。
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