Kruglikov Ilja L, Zhang Zhuzhen, Scherer Philipp E
Scientific Department, Wellcomet GmbH, 76646 Bruchsal, Germany.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA.
Int J Mol Sci. 2022 Mar 30;23(7):3828. doi: 10.3390/ijms23073828.
Adipocytes from the superficial layer of subcutaneous adipose tissue undergo cyclic de- and re-differentiation, which can significantly influence the development of skin inflammation under different cutaneous conditions. This inflammation can be connected with local loading of the reticular dermis with lipids released due to de-differentiation of adipocytes during the catagen phase of the hair follicle cycle. Alternatively, the inflammation parallels a widespread release of cathelicidin, which typically takes place in the anagen phase (especially in the presence of pathogens). Additionally, trans-differentiation of dermal adipocytes into myofibroblasts, which can occur under some pathological conditions, can be responsible for the development of collateral scarring in acne. Here, we provide an overview of such cellular conversions in the skin and discuss their possible involvement in the pathophysiology of inflammatory skin conditions, such as acne and psoriasis.
来自皮下脂肪组织表层的脂肪细胞经历周期性的去分化和再分化，这在不同的皮肤状况下会显著影响皮肤炎症的发展。这种炎症可能与毛囊周期退行期脂肪细胞去分化释放的脂质在网状真皮中的局部蓄积有关。或者，炎症与抗菌肽的广泛释放同时发生，抗菌肽的释放通常发生在生长期（尤其是在有病原体存在的情况下）。此外，真皮脂肪细胞向肌成纤维细胞的转分化在某些病理条件下可能发生，这可能是痤疮中形成旁侧瘢痕的原因。在此，我们概述了皮肤中的此类细胞转化，并讨论了它们可能参与痤疮和银屑病等炎症性皮肤病的病理生理学过程。
