通过区域选择性的统一保护/脱保护策略合成碳水化合物砌块。
Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies.
机构信息
Department of Chemistry and Biochemistry, University of Missouri - St Louis, One University Boulevard, St Louis, Missouri 63121, USA.
出版信息
Org Biomol Chem. 2019 May 28;17(20):4934-4950. doi: 10.1039/c9ob00573k. Epub 2019 May 2.
Abstract
Discussed herein is the synthesis of partially protected carbohydrates by manipulating only one type of a protecting group for a given substrate. The first focus of this review is the uniform protection of an unprotected starting material in a way that only one (or two) hydroxyl group remains unprotected. The second focus involves regioselective partial deprotection of uniformly protected compounds in a way that only one (or two) hydroxyl group becomes liberated.
摘要
本文讨论了仅通过操纵给定底物的一种保护基团来合成部分保护的碳水化合物。本综述的第一个重点是通过仅保留一个（或两个）羟基来统一保护未保护的起始原料。第二个重点涉及通过仅使一个（或两个）羟基游离来选择性地部分脱保护均匀保护的化合物。
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