放射治疗增加口腔癌患者带状疱疹的发病率——一项基于全国人口的队列研究。
Radiotherapy Increases the Incidence of Herpes Zoster in Oral Cavity Cancer Patients - a National Population-based Cohort Study.
作者信息
Kao Yung-Shuo, Hsu Yen, Hsu Chung Y
机构信息
Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
Department of Family Medicine, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
出版信息
In Vivo. 2021 Nov-Dec;35(6):3547-3553. doi: 10.21873/invivo.12657.
BACKGROUND/AIM: Oral cavity cancer is a major health problem worldwide. The herpes zoster vaccine is an effective method to protect against herpes zoster infection. In this study we aimed to determine the relationship between herpes zoster and oral cavity cancer.
PATIENTS AND METHODS
The Longitudinal Generation Tracking Database in Taiwan was used to select oral and non-oral cavity cancer patients. The primary endpoint was herpes zoster.
RESULTS
We included 3131 oral cavity cancer patients and 3131 non-oral cavity cancer patients. Patients with oral cavity cancer [adjusted hazard ratio (HR)=1.66, 95% confidence interval (CI)=1.27-2.16] had a significantly higher risk of herpes zoster compared to the control group. The oral cavity patients who received radiotherapy (adjusted HR=1.79, 95%CI=1.12-2.86) had a significantly higher risk of herpes zoster compared to the oral cavity patients who did not receive radiotherapy.
CONCLUSION
Radiotherapy increases the incidence of herpes zoster infection in oral cavity cancer patients.
背景/目的：口腔癌是全球范围内的一个主要健康问题。带状疱疹疫苗是预防带状疱疹感染的一种有效方法。在本研究中，我们旨在确定带状疱疹与口腔癌之间的关系。
患者与方法
使用台湾纵向世代追踪数据库选取口腔癌和非口腔癌患者。主要终点为带状疱疹。
结果
我们纳入了3131例口腔癌患者和3131例非口腔癌患者。与对照组相比，口腔癌患者[调整后风险比（HR）=1.66，95%置信区间（CI）=1.27 - 2.16]发生带状疱疹的风险显著更高。接受放疗的口腔癌患者（调整后HR = 1.79，95%CI = 1.12 - 2.86）与未接受放疗的口腔癌患者相比，发生带状疱疹的风险显著更高。
结论
放疗会增加口腔癌患者带状疱疹感染的发生率。
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