McUmber Harrison, Dabek Robert J, Bojovic Branko, Driscoll Daniel N
Tufts University School of Medicine, Boston, Massachusetts.
Department of Surgery, Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston.
J Burn Care Res. 2019 Jun 21;40(4):513-516. doi: 10.1093/jbcr/irz054.
Distinguishing between partial-thickness burns and full-thickness burns indicates the critical decision making related to whether a patient can be allowed to heal on their own or if the wound should be surgically excised and replaced with a graft. Therefore, reliable burn prognostication is crucial in planning the safest and most cost-effective treatment for the patient. Over the course of the last several decades, many techniques have been proposed and used to determine burn depth; namely, laser Doppler imaging and thermogenic assessment. Recently, indocyanine green (ICG), a fluorescent dye which is administered intravenously to measure tissue perfusion in real time, has been the focus of research regarding its efficacy in assessing burns. Studies have been conducted using rat, porcine, and human models. We have assessed and critically reviewed this literature to provide the burn community with a narrative of the promising potential of ICG to diagnose burn depth. ICG can measure perfusion instantaneously and in real time via video capture. This allows for evaluation of ICG uptake, standard state distribution, and clearance of the dye which with further study could increase the precision of the technique. In conclusion, ICG videoangiography shows a great deal of promise in being a particularly effective way of diagnosing burn depth and warrants further studies to investigate the best way for this technique to be used in a clinical setting.
区分浅度烧伤和深度烧伤对于决定患者是可自行愈合还是需通过手术切除伤口并进行植皮至关重要。因此，可靠的烧伤预后评估对于为患者制定最安全、最具成本效益的治疗方案至关重要。在过去几十年中，人们提出并使用了许多技术来确定烧伤深度，即激光多普勒成像和热生成评估。最近，吲哚菁绿（ICG），一种通过静脉注射用于实时测量组织灌注的荧光染料，已成为评估烧伤疗效研究的焦点。已使用大鼠、猪和人体模型进行了研究。我们对这些文献进行了评估和批判性审查，以便向烧伤领域的人士介绍ICG在诊断烧伤深度方面的潜在前景。ICG可通过视频捕捉即时、实时地测量灌注情况。这有助于评估ICG的摄取、标准状态分布以及染料的清除情况，随着进一步研究，该技术的精度可能会提高。总之，ICG视频血管造影术在诊断烧伤深度方面显示出巨大潜力，有望成为一种特别有效的方法，值得进一步研究以探索在临床环境中使用该技术的最佳方式。
