Matalia Jyoti, Vinekar Anand, Anegondi Neha, Mangalesh Shwetha, Anaspure Hemant, Shetty K Bhujang, Sinha Roy Abhijit
Pediatric Ophthalmology Services, Narayana Nethralaya Eye Hospital, Bangalore, India.
Pediatric Retina Services, Narayana Nethralaya, Bangalore, India.
Ophthalmol Retina. 2018 Dec;2(12):1235-1240. doi: 10.1016/j.oret.2018.06.003. Epub 2018 Jul 17.
To analyze rubella retinopathy qualitatively and quantitatively in children diagnosed with congenital rubella syndrome (CRS) using a handheld spectral-domain (SD) OCT device.
Prospective, cross-sectional, nonrandomized, comparative observational study in a tertiary eye care center in south India.
Cases comprised 24 eyes of 13 children diagnosed with CRS based on seropositivity with rubella retinopathy. Controls comprised 26 eyes of 13 age-matched healthy children with normal retina.
All participants underwent retinal imaging with RetCam fundus photography (Natus Medical Inc, Pleasanton, CA) and handheld SD OCT (Bioptigen, Inc., Durham, NC). The SD OCT images of both cases and controls were segmented. Retinal and choroid thickness parameters were computed.
Qualitative and quantitative changes were observed in SD OCT images of rubella retinopathy compared with those from controls.
Characteristic salt-and-pepper appearance was observed on fundus photography in children with rubella compared with the healthy children. The appearance of fovea and retinal features such as foveal dip, external limiting membrane, inner segment-outer segment boundary, outer segment-retinal pigment epithelium boundary, and retinal pigment epithelium were significantly different (P < 0.05) in eyes with rubella retinopathy compared with healthy eyes Furthermore, eyes with rubella retinopathy exhibited significantly reduced central foveal thickness (P = 0.025), subfoveal outer retinal thickness (P = 0.01), and subfoveal choroid thickness (P = 0.007) compared with healthy eyes.
Distinct qualitative and quantitative differences were observed in the SD OCT images of eyes with rubella retinopathy compared with those from healthy eyes.
使用手持式光谱域（SD）光学相干断层扫描（OCT）设备对诊断为先天性风疹综合征（CRS）的儿童风疹视网膜病变进行定性和定量分析。
在印度南部一家三级眼科护理中心进行的前瞻性、横断面、非随机、对比观察研究。
病例组包括13名基于风疹视网膜病变血清学阳性诊断为CRS的儿童的24只眼。对照组包括13名年龄匹配、视网膜正常的健康儿童的26只眼。
所有参与者均接受RetCam眼底摄影（Natus Medical Inc，普莱森顿，加利福尼亚州）和手持式SD OCT（Bioptigen，Inc.，达勒姆，北卡罗来纳州）进行视网膜成像。对病例组和对照组的SD OCT图像进行分割。计算视网膜和脉络膜厚度参数。
将风疹视网膜病变的SD OCT图像与对照组的图像进行比较，观察定性和定量变化。
与健康儿童相比，风疹患儿眼底摄影可见特征性的椒盐样外观。风疹视网膜病变患儿的黄斑外观以及视网膜特征，如黄斑凹陷、外界膜、内节-外节边界、外节-视网膜色素上皮边界和视网膜色素上皮，与健康眼相比有显著差异（P<0.05）。此外，与健康眼相比，风疹视网膜病变患儿的中心凹厚度（P = 0.025）、黄斑下视网膜外层厚度（P = 0.01）和黄斑下脉络膜厚度（P = 0.007）显著降低。
与健康眼相比，风疹视网膜病变眼的SD OCT图像存在明显的定性和定量差异。
