Vatavuk Zoran, Andrijević Derk Biljana, Knežević Tamara, Belak Marin, Milošević Milan, Friberg Thomas R
University Clinical Centre "Sestre milosrdnice," Eye Clinic, Zagreb, Croatia.
University Clinical Centre "Sestre milosrdnice," Eye Clinic, Zagreb, Croatia.
Ophthalmol Retina. 2018 Mar;2(3):201-208. doi: 10.1016/j.oret.2017.06.013. Epub 2017 Sep 22.
To show morphologic and angiographic changes in the peripheral retina in patients with age-related macular degeneration (AMD) using wide-field fundus imaging, and to compare these findings with those from healthy controls.
Cross-sectional clinical study.
In total, 152 patients with clinical AMD and 150 healthy controls (without AMD in either macula) were studied. Subjects were ≥50 years of age. Exclusion criteria were diabetic retinopathy, previous retinal surgery, high myopia, or dense cataract, as well as any retinal inflammatory, degenerative, or occlusive disease.
For both groups of patients, color fundus images were captured with the Optos P200 MA camera (Optos, Dunfermline, Scotland). Image analysis software was used to characterize each image. Angiography was performed on the AMD group only. Morphological and angiographic peripheral retinal changes were studied per the frequency of their occurrence, the affected peripheral retina (clock hours), and the localization of peripheral changes with regard to the eye equator. Statistical significance was defined at a level of P < 0.05.
Peripheral changes in both groups according to their type and frequency (percentage of eyes with detected retinal changes), the number of clock hours of affected peripheral retina, and their localization with regard to the equator of the eye.
Drusen, reticular pigmentary changes, and paving stone degeneration occurred more frequently in the AMD group than in controls (P < 0.001, P < 0.001, and P < 0.001 respectively), whereas white without pressure occurred more frequently in the control group (P = 0.027). In both groups, peripheral retinal changes were observed peripheral to the equator in more than 40% of analyzed eyes. In control Croatian subjects, peripheral drusen were seen in 38% of subjects compared with 68% of AMD subjects.
Drusen, reticular pigmentary change , and paving stone degeneration occur significantly more frequently in subjects with AMD compared with controls. White without pressure degeneration was present in a high percentage of control subjects.
使用广角眼底成像技术显示年龄相关性黄斑变性（AMD）患者周边视网膜的形态学和血管造影变化，并将这些结果与健康对照者的结果进行比较。
横断面临床研究。
共研究了152例临床诊断为AMD的患者和150名健康对照者（双眼黄斑均无AMD）。受试者年龄≥50岁。排除标准包括糖尿病视网膜病变、既往视网膜手术史、高度近视、致密性白内障，以及任何视网膜炎症、退行性或闭塞性疾病。
两组患者均使用Optos P200 MA相机（Optos，邓弗姆林，苏格兰）拍摄彩色眼底图像。使用图像分析软件对每张图像进行特征描述。仅对AMD组进行血管造影。根据周边视网膜变化的发生频率、受影响的周边视网膜（钟点数）以及周边变化相对于眼赤道的定位，研究形态学和血管造影周边视网膜变化。统计学显著性定义为P<0.05。
两组根据周边变化的类型和频率（检测到视网膜变化的眼的百分比）、受影响的周边视网膜的钟点数以及它们相对于眼赤道的定位情况。
玻璃膜疣、网状色素改变和铺路石样变性在AMD组中比对照组更频繁出现（分别为P<0.001、P<0.001和P<0.001），而无压白变在对照组中更频繁出现（P=0.027）。在两组中，超过40%的分析眼中在赤道以外观察到周边视网膜变化。在克罗地亚对照组受试者中，38%的受试者出现周边玻璃膜疣，而AMD受试者中这一比例为68%。
与对照组相比，AMD患者中玻璃膜疣、网状色素改变和铺路石样变性的发生频率显著更高。无压白变在对照组受试者中占很高比例。
