中性粒细胞 CD11b 是否为新生儿脓毒症早期诊断的特异性标志物？系统评价和荟萃分析。
Is neutrophil CD11b a special marker for the early diagnosis of sepsis in neonates? A systematic review and meta-analysis.
机构信息
Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, China.
出版信息
BMJ Open. 2019 May 1;9(4):e025222. doi: 10.1136/bmjopen-2018-025222.
OBJECTIVES
Our study aimed to synthesise and analyse the early diagnostic value of neutrophil CD11b (nCD11b) for neonatal sepsis.
DESIGN
Systematic review and meta-analysis.
METHODS
Pubmed, Embase, the Cochrane Library and Web of Science Databases were searched up to June 2018. We used Stata software (V.14.0) to conduct the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic OR (DOR), pretest probability, post-test probability and summary receiver operating characteristic (SROC) curve for diagnostic efficiency of n CD11b.
RESULTS
Nine studies, accounting for 843 neonates, were included. The overall pooled sensitivity, specificity, PLR, NLR, DOR, post-test positive probability and post-test negative probability and the area under the SROC curve were 0.82 (95% CI 0.71 to 0.90), 0.93 (95% CI 0.62 to 0.99), 11.51 (95% CI 1.55 to 85.62), 0.19 (95% CI 0.10 to 0.36), 59.50 (95% CI 4.65 to 761.58), 74%, 5% and 0.90, which had accuracy in diagnosing neonatal sepsis.
CONCLUSION
The present evidence indicated that nCD11b is a promising biomarker for the early diagnosis of neonatal sepsis.
目的
本研究旨在综合分析中性粒细胞 CD11b（nCD11b）对新生儿败血症的早期诊断价值。
设计
系统评价和荟萃分析。
方法
检索 Pubmed、Embase、Cochrane 图书馆和 Web of Science 数据库，检索时间截至 2018 年 6 月。使用 Stata 软件（V.14.0）对 nCD11b 的诊断效率进行汇总敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）、预试验概率、后验概率和汇总受试者工作特征（SROC）曲线分析。
结果
纳入 9 项研究，共 843 例新生儿。汇总的敏感性、特异性、PLR、NLR、DOR、后验阳性概率和后验阴性概率以及 SROC 曲线下面积分别为 0.82（95%CI 0.71 至 0.90）、0.93（95%CI 0.62 至 0.99）、11.51（95%CI 1.55 至 85.62）、0.19（95%CI 0.10 至 0.36）、59.50（95%CI 4.65 至 761.58）、74%、5%和 0.90，诊断新生儿败血症的准确性较高。
结论
目前的证据表明，nCD11b 是新生儿败血症早期诊断的有前途的生物标志物。
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