肝细胞癌的自发消退及英文文献报道综述
Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature.
作者信息
Chohan Moaz B Y, Taylor Nick, Coffin Carla, Burak Kelly W, Bathe Oliver F
机构信息
Departments of Surgery, University of Calgary, Calgary, AB, Canada.
Departments of Medicine, University of Calgary, Calgary, AB, Canada.
出版信息
Case Rep Med. 2019 Mar 31;2019:9756758. doi: 10.1155/2019/9756758. eCollection 2019.
BACKGROUND
Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, although it has been described by numerous groups. The long-term fate of individuals experiencing an SR is not well described, and the underlying mechanism(s) of SR are unknown. : A 79-year-old Asian female with metastatic HCC taking only valsartan for hypertension had a marked reduction in tumor dimension in the primary tumor and the pulmonary metastases. Serum alpha-fetoprotein (AFP) decreased from 17,833 g/L to 26 g/L. Her disease progressed after 71 months, and she died shortly after. In a review of 66 patients with SR reported in the English literature, median survival was 83 months. Median survival in 37 cases that underwent resection after SR was 108 months.
CONCLUSIONS
The case and a review of the literature illustrate that SR is often durable and associated with an excellent prognosis. Understanding the underlying mechanism of SR may point to novel therapeutic strategies.
背景
肝细胞癌（HCC）的自发消退是一种罕见事件，尽管已有多个研究小组对此进行过描述。经历自发消退（SR）的个体的长期预后情况描述不详，且SR的潜在机制尚不清楚。一名79岁的亚洲女性，患有转移性HCC，仅服用缬沙坦治疗高血压，其原发肿瘤和肺转移灶的肿瘤大小显著减小。血清甲胎蛋白（AFP）从17,833 μg/L降至26 μg/L。71个月后其病情进展，不久后死亡。在对英文文献报道的66例SR患者的回顾中，中位生存期为83个月。37例SR后接受切除术的患者的中位生存期为108个月。
结论
该病例及文献回顾表明，SR通常具有持续性且预后良好。了解SR的潜在机制可能会指向新的治疗策略。
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