Li Weinan, Xiong Yongfu, Shu Xia, Li Jingdong
Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Department of Gastroenterology, First People's Hospital of Longquanyi District, Chengdu, China.
Front Surg. 2022 Sep 12;9:972446. doi: 10.3389/fsurg.2022.972446. eCollection 2022.
Spontaneous regression of primary liver cancer is a rare event, and currently the exact pathogenesis of spontaneous tumor regression remains unclear.
Clinical information was collected from a patient with spontaneous regression of liver cancer at our center. The patient was a 41-year-old male. He was admitted to the hospital on 3 May 2019, due to aversion to fatty or greasy food, anorexia, loss of appetite, and abdominal distension. Laboratory examination results included hepatitis B surface antigen positivity, hepatitis B e antigen positivity, and hepatitis B core antibody positivity and tumor marker levels of alpha-fetoprotein 142,938.20 µg/L, abnormal prothrombin 4,599.91 mAU/ml, and carbohydrate antigen 19-9 82.05 U/ml. Upper abdominal enhanced computed tomography indicated right hepatocellular carcinoma with portal vein tumor thrombus formation. The patient declined any treatment. The tumor in the right lobe of the liver completely regressed after 1 year, and the patient is still undergoing follow-up.
We encountered a hepatocellular carcinoma patient who underwent spontaneous regression, but the exact pathogenesis remains unknown. Understanding the pathogenesis of spontaneous regression of hepatocellular carcinoma has the potential to contribute to the development of an effective treatment for hepatocellular carcinoma.
原发性肝癌的自发消退是一种罕见事件，目前肿瘤自发消退的确切发病机制仍不清楚。
我们从本中心一名肝癌自发消退患者处收集了临床信息。该患者为41岁男性。他于2019年5月3日因厌油腻食物、厌食、食欲不振和腹胀入院。实验室检查结果包括乙肝表面抗原阳性、乙肝e抗原阳性、乙肝核心抗体阳性，以及肿瘤标志物甲胎蛋白水平为142,938.20 µg/L、异常凝血酶原4,599.91 mAU/ml和糖类抗原19-9 82.05 U/ml。上腹部增强计算机断层扫描显示右肝细胞癌伴门静脉癌栓形成。患者拒绝任何治疗。肝脏右叶肿瘤在1年后完全消退，患者仍在接受随访。
我们遇到了一名肝细胞癌自发消退的患者，但其确切发病机制仍然未知。了解肝细胞癌自发消退的发病机制可能有助于开发有效的肝细胞癌治疗方法。
