Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
Nanomedicine (Lond). 2019 May;14(9):1109-1133. doi: 10.2217/nnm-2018-0413. Epub 2019 May 3.
To improve the bioactivity and antibacterial activity of titanium (Ti) implants. Magnesium (Mg)-doped titanium dioxide microporous coatings (Mg-TiO) were prepared on the surface of Ti implants by plasma electrolytic oxidation. Ti surfaces were covered with porous Mg-TiO, and Mg was evenly distributed throughout the coating. Mg-TiO could not only promote osteoblast adhesion, proliferation and differentiation but also inhibit the colonization and growth of . In addition, Mg-TiO may promote osteogenesis through the ERK/c-Fos signaling pathway as well as the early osseointegration of Ti implants. Mg-TiO has both osteogenic and antibacterial effects and thus presents important theoretical significance and clinical potential.
为了提高钛（Ti）植入物的生物活性和抗菌活性。通过等离子体电解氧化在 Ti 植入物表面制备了掺镁二氧化钛微孔涂层（Mg-TiO）。Ti 表面覆盖有多孔 Mg-TiO，Mg 均匀分布在整个涂层中。Mg-TiO 不仅可以促进成骨细胞的黏附、增殖和分化，还可以抑制 的定植和生长。此外，Mg-TiO 可能通过 ERK/c-Fos 信号通路以及 Ti 植入物的早期骨整合来促进成骨作用。Mg-TiO 具有成骨和抗菌作用，因此具有重要的理论意义和临床应用潜力。
