Charité-Universitätsmedizin Berlin, Department of Pediatric Oncology, D-13353 Berlin, Germany.
Berlin Institute of Health (BIH), D-10178 Berlin, Germany.
Int J Mol Sci. 2019 Apr 30;20(9):2150. doi: 10.3390/ijms20092150.
Non-coding RNAs (ncRNAs) are essential regulators of gene expression. In recent years, it has become more and more evident that the different classes of ncRNAs, such as micro RNAs, long non-coding RNAs and circular RNAs are organized in tightly controlled networks. It has been suggested that deregulation of these networks can lead to disease. Several studies show a contribution of these so-called competing-endogenous RNA networks in various cancer entities. In this review, we highlight the involvement of ncRNA networks in anaplastic-large cell lymphoma (ALCL), a T-cell neoplasia. A majority of ALCL cases harbor the molecular hallmark of this disease, a fusion of the anaplastic lymphoma kinase (ALK) gene with the nucleophosmin (NPM, NPM1) gene leading to a permanently active kinase that promotes the malignant phenotype. We have focused especially on ncRNAs that are regulated by the - fusion gene and illustrate how their deregulation contributes to the pathogenesis of ALCL. Lastly, we summarize the findings and point out potential therapeutic implications.
非编码 RNA（ncRNA）是基因表达的重要调控因子。近年来，越来越明显的是，不同类型的 ncRNA，如 microRNA、长非编码 RNA 和环状 RNA，是在紧密控制的网络中组织的。有人认为，这些网络的失调可能导致疾病。几项研究表明，这些所谓的竞争内源性 RNA 网络在各种癌症实体中都有贡献。在这篇综述中，我们强调了 ncRNA 网络在间变性大细胞淋巴瘤（ALCL）中的参与，ALCL 是一种 T 细胞肿瘤。大多数 ALCL 病例都具有该疾病的分子特征，即间变性淋巴瘤激酶（ALK）基因与核仁磷酸蛋白（NPM，NPM1）基因融合，导致永久性激活的激酶促进恶性表型。我们特别关注受 - 融合基因调控的 ncRNA，并说明它们的失调如何导致 ALCL 的发病机制。最后，我们总结了研究结果，并指出了潜在的治疗意义。
