Perez de Acha Olivia, Rossi Martina, Gorospe Myriam
Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, United States.
Front Mol Biosci. 2020 Jun 26;7:109. doi: 10.3389/fmolb.2020.00109. eCollection 2020.
Circular (circ)RNAs influence a wide range of biological processes at least in part by interacting with proteins and microRNAs. CircRNAs expressed in the hematopoietic compartment have been increasingly recognized as modulators of physiological and pathological features of hematopoetic stem cell (HSC)-derived populations. In particular, several circRNAs were found to enhance or suppress tumor progression in blood malignancies such as leukemias and lymphomas. Moreover, numerous circRNAs have been proposed to help confer resistance to the conventional treatments used in hematopoietic cancers. Here, we review the most important circRNAs described thus far in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), lymphomas, and multiple myeloma (MM). We discuss the usefulness of circRNAs as diagnostic and prognostic markers and their potential value as therapeutic targets.
环状（circ）RNA至少部分地通过与蛋白质和微小RNA相互作用来影响广泛的生物学过程。在造血区室中表达的circRNA越来越被认为是造血干细胞（HSC）衍生群体生理和病理特征的调节因子。特别是，发现几种circRNA可增强或抑制白血病和淋巴瘤等血液恶性肿瘤中的肿瘤进展。此外，许多circRNA被认为有助于赋予对造血癌症中使用的传统治疗的抗性。在这里，我们回顾了迄今为止在急性髓性白血病（AML）、慢性髓性白血病（CML）、急性淋巴细胞白血病（ALL）、慢性淋巴细胞白血病（CLL）、淋巴瘤和多发性骨髓瘤（MM）中描述的最重要的circRNA。我们讨论了circRNA作为诊断和预后标志物的有用性及其作为治疗靶点的潜在价值。
