Halal Research Center of IRI, FDA, Tehran, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Eur J Clin Nutr. 2020 Apr;74(4):543-547. doi: 10.1038/s41430-019-0434-9. Epub 2019 May 3.
This study aimed to systematically review randomized clinical trials (RCTs) to clarify the effects of pro-/synbiotic supplementation on anthropometric and biochemical measurements in women with polycystic ovary syndrome (PCOS). PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar were searched through September 2018. Eight RCTs (nine treatment arms) were included. Pro-/synbiotic supplementation significantly reduced fasting blood sugar (-2.52 mg/dl, 95% confidence interval (CI): -4.10 to -0.95), insulin (-2.27 µIU/mL, 95% CI: -3.40 to -1.14), homeostasis model assessment for insulin resistance index (-0.69, 95% CI: -0.98 to -0.40), C-reactive protein (-1.69 Hedges', 95% CI: -3.00 to -0.38), and total testosterone (-0.12 ng/mL, 95% CI: -0.17 to -0.08) in women with PCOS. However, changes in the mean difference of weight and body mass index did not reach a statistically significant level. The findings suggest that pro-/synbiotic supplementation may improve glucose homeostasis parameters, hormonal, and inflammatory indices in women with PCOS.
本研究旨在系统综述随机临床试验（RCT），以明确益生菌/合生剂补充对多囊卵巢综合征（PCOS）妇女人体测量学和生化指标的影响。通过 2018 年 9 月检索 PubMed、Scopus、ISI Web of Science、Cochrane Library 和 Google Scholar。共纳入 8 项 RCT（9 个治疗组）。益生菌/合生剂补充可显著降低空腹血糖（-2.52mg/dl，95%置信区间（CI）：-4.10 至-0.95）、胰岛素（-2.27µIU/mL，95%CI：-3.40 至-1.14）、胰岛素抵抗指数评估的稳态模型（-0.69，95%CI：-0.98 至-0.40）、C 反应蛋白（-1.69 Hedge's，95%CI：-3.00 至-0.38）和总睾酮（-0.12ng/mL，95%CI：-0.17 至-0.08）。然而，体重和体重指数的平均差值变化未达到统计学显著水平。这些发现表明，益生菌/合生剂补充可能改善 PCOS 妇女的葡萄糖稳态参数、激素和炎症指标。
