Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Inflammopharmacology. 2023 Oct;31(5):2253-2268. doi: 10.1007/s10787-023-01332-8. Epub 2023 Sep 12.
Despite the increasing evidence for probiotics' anti-inflammatory effects, the results of meta-analyses remain inconsistent. The present umbrella meta-analysis aimed to investigate the effects of probiotic supplementation on inflammatory biomarkers.
We performed a wide-ranging systematic search in several databases, including PubMed, Web of Science, Scopus, EMBASE, and Google Scholar up to April 2023. The overall effect sizes were calculated using effect size (ES) values and their corresponding confidence intervals (CI).
Out of a total of 580 related articles, 39 studies were qualified for inclusion in the analysis. The results of the analysis revealed a significant reduction of C-reactive protein (CRP) (ES = -1.02; 95% CI: -1.23, -0.80, p < 0.001; I: 94.1%, p < 0.001), TNF-α (ES = -0.35; 95% CI: -0.50, -0.20, p < 0.001; I: 75.6%, p < 0.001), and interleukin-6 (IL-6) levels (ES = -0.36; 95% CI: -0.59, -0.13, p = 0.002; I: 85.6%, p < 0.001), following probiotic supplementation.
Probiotic supplementation significantly reduced serum concentrations of TNF-a, CRP, and IL-6. Thus, probiotic supplementation can be considered adjuvant therapy to alleviate inflammation in various inflammatory conditions.
尽管越来越多的证据表明益生菌具有抗炎作用，但荟萃分析的结果仍不一致。本伞式荟萃分析旨在研究益生菌补充对炎症生物标志物的影响。
我们在多个数据库（包括 PubMed、Web of Science、Scopus、EMBASE 和 Google Scholar）中进行了广泛的系统搜索，截至 2023 年 4 月。使用效应量（ES）值及其相应置信区间（CI）计算总体效应大小。
在总共 580 篇相关文章中，有 39 项研究符合纳入分析的标准。分析结果表明，C 反应蛋白（CRP）（ES=-1.02；95%CI：-1.23，-0.80，p<0.001；I：94.1%，p<0.001）、肿瘤坏死因子-α（TNF-α）（ES=-0.35；95%CI：-0.50，-0.20，p<0.001；I：75.6%，p<0.001）和白细胞介素-6（IL-6）水平（ES=-0.36；95%CI：-0.59，-0.13，p=0.002；I：85.6%，p<0.001）显著降低。
益生菌补充剂可显著降低 TNF-a、CRP 和 IL-6 的血清浓度。因此，益生菌补充剂可被视为辅助治疗，以减轻各种炎症状态下的炎症。
