Maloberti Alessandro, Vallerio Paola, Triglione Nicola, Occhi Lucia, Panzeri Francesco, Bassi Ilaria, Pansera Francesco, Piccinelli Enrico, Peretti Alessio, Garatti Laura, Palazzini Matteo, Sun Jinwei, Grasso Enzo, Giannattasio Cristina
School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Cardiology 4, "A. De Gasperis" Department, Niguarda Ca Granda Hospital, Piazza Ospedale Maggiore 3, 20159, Milan, Italy.
High Blood Press Cardiovasc Prev. 2019 Jun;26(3):175-182. doi: 10.1007/s40292-019-00318-4. Epub 2019 May 3.
Structural and functional arterial properties commonly impair with aging process. These effects on vasculature could act at many levels from microcirculation to large vessels. Above normal aging process classic cardio-vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, etc.) accelerate the physiological process leading to premature structural and functional alterations that has also been termed early vascular aging. Target organ damage evaluation could be clinically important since these alterations precede by many years' cardiovascular events and so their assessment can predict the onset of more serious and costly events giving the opportunity to prevent CV events by earlier therapeutic intervention. This review will focus on large artery functional properties and particularly on the role of inflammation on the aortic stiffening process.
动脉的结构和功能特性通常会随着衰老过程而受损。这些对脉管系统的影响可在从微循环到大型血管的多个层面发挥作用。在正常衰老过程之上，典型的心血管危险因素（高血压、糖尿病、血脂异常等）会加速生理过程，导致过早出现结构和功能改变，这也被称为早期血管衰老。靶器官损害评估在临床上可能很重要，因为这些改变比心血管事件早很多年出现，所以对它们的评估可以预测更严重且代价更高的事件的发生，从而有机会通过早期治疗干预来预防心血管事件。本综述将聚焦于大动脉的功能特性，尤其关注炎症在主动脉硬化过程中的作用。
