Shalygina N B, Shepeleva G K, Astrina O S, Lomazova Kh D, Poliakova A M
Arkh Patol. 1987;49(2):27-32.
Histological and biomicroscopic methods were used to study the effects of toxic lemic and meningococcal microbial fractions on mesenteric blood microcirculation in rats. Aggregation ability of red blood cells and thrombocytes was investigated. The sublethal dose of meningococcal toxins was shown to induce marked impairment in the blood microcirculation 30 minutes after intravenous administration. The lethal dose of lemic toxins manifests itself later (in 2-4 hours). Meningococcal toxins are characterized by the increase in the aggregation ability of erythrocytes and thrombocytes in initial observation periods; lemic toxins increase the thrombocyte aggregation and produce almost no effect on erythrocyte aggregation.
采用组织学和生物显微镜方法研究有毒的鼠疫和脑膜炎球菌微生物组分对大鼠肠系膜血液微循环的影响。研究了红细胞和血小板的聚集能力。结果显示，静脉注射亚致死剂量的脑膜炎球菌毒素后30分钟，血液微循环出现明显损伤。鼠疫毒素的致死剂量作用出现较晚（2 - 4小时）。脑膜炎球菌毒素的特点是在最初观察期红细胞和血小板的聚集能力增加；鼠疫毒素则增加血小板聚集，对红细胞聚集几乎没有影响。
