Icahn School of Medicine at Mount Sinai West and St. Luke's Hospitals, Department of Anesthesiology, Perioperative and Pain Medicine, New York, NY, USA.
Icahn School of Medicine at Mount Sinai West and St. Luke's Hospitals, Department of Anesthesiology, Perioperative and Pain Medicine, New York, NY, USA.
Br J Anaesth. 2019 Aug;123(2):e424-e433. doi: 10.1016/j.bja.2019.03.030. Epub 2019 May 2.
Complex regional pain syndrome (CRPS) is a life-altering condition that usually affects the extremities after a trauma or nerve injury. The physiologic changes that occur as a result of the inciting injury are complex, as the name of the syndrome implies. The pain and disability associated with CRPS often lead to psychological co-morbidities that create a vicious cycle of pain, isolation, and depression. We review recent developments in the understanding of CRPS and advancements in management of this syndrome. Further research in targeting specific mechanisms involved in the pathophysiology of CRPS should lead to prevention of this condition.
复杂性区域疼痛综合征（CRPS）是一种改变生活的疾病，通常在创伤或神经损伤后影响四肢。正如该综合征的名称所示，由于激发性损伤而发生的生理变化是复杂的。与 CRPS 相关的疼痛和残疾常常导致心理合并症，从而形成疼痛、孤立和抑郁的恶性循环。我们回顾了对 CRPS 的理解的最新进展和对该综合征的管理的进展。针对 CRPS 病理生理学中涉及的特定机制的进一步研究应能预防这种疾病。
