State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Medicine of Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
College of Stomatology, Chongqing Medical University, Chongqing, China.
Oral Dis. 2020 May;26(4):719-732. doi: 10.1111/odi.13115. Epub 2019 Jul 26.
Oral squamous cell carcinoma (OSCC) is a common malignancy with dismal prognosis without effective therapeutic options in advanced cases. The evolution from oral potentially malignant disorders to OSCC has poorly described underlying epigenetic features. With the ability of silencing or activation of vital genes, histone modifications' and modifiers' potentiality for early diagnosis, prognosis predicting, and therapy in OSCC were evaluated by extensive epigenetic studies. This review investigates the roles of dysregulated histone modifications and the associated modifying enzymes in OSCC onset and progression. Also, we focus on the current advances of histone modifications as therapeutic targets and the potential value of epi-drugs.
口腔鳞状细胞癌（OSCC）是一种常见的恶性肿瘤，如果在晚期没有有效的治疗选择，预后往往较差。从口腔潜在恶性疾病到 OSCC 的发展过程中，其潜在的表观遗传特征描述得很差。由于组蛋白修饰及其修饰酶具有沉默或激活重要基因的能力，因此通过广泛的表观遗传研究来评估它们在 OSCC 中的早期诊断、预后预测和治疗的潜力。本综述探讨了失调的组蛋白修饰及其相关修饰酶在 OSCC 发生和发展中的作用。此外，我们还重点介绍了组蛋白修饰作为治疗靶点的最新进展以及 epi-drugs 的潜在价值。
