不同根管内药物对[具体细菌名称1]和[具体细菌名称2]抗菌活性的评估：一项体外研究。（注：原文中“against and ”处具体细菌名称缺失）

Assessment of Antimicrobial Activity of Different Intracanal Medicaments against and : An Study.

作者信息

Jayakkodi Harikaran, Reddy Asha, Krishnan Vineesh, Arora Suraj, Cv Renjith Raj, Joseph Sona

机构信息

Department of Conservative Dentistry and Endodontics, Educare Institute of Dental Sciences, Malappuram, Kerala, India, Phone: +919486254882, e-mail:

Department of Conservative Dentistry and Endodontics, Sri Balaji Dental College, Moinabad, Hyderabad, India.

出版信息

J Contemp Dent Pract. 2019 Feb 1;20(2):179-183.

PMID:31058632

Abstract

AIM

The aim of the present study was to compare the anti-microbial efficacy of various intracanal medicaments against and Materials and methods: Sixty single rooted, non-carious, permanent mandibular premolars with no developmental defects that were previously extracted for the orthodontic purpose were included in this study. and strains were cultured on brain heart infusion (BHI) and sabouraud dextrose (SD) agar plates respectively. Sixty specimens were divided into two main groups and three subgroups with 10 teeth receiving a medicament; group I: (Subgroup Ia: BioPure MTAD, Subgroup Ib: propolis, Subgroup Ic: Triple antibiotic paste), group II: (Subgroup IIa: BioPure MTAD, Subgroup IIb: propolis, Subgroup IIc: Triple antibiotic paste). The antimicrobial activity of the intracanal medicaments against E. faecalis and C. albicans were assessed at the end of 2nd and 7th day. The mean zones of inhibition were analyzed with a one-way ANOVA test.

RESULTS

After 2 days, the mean zone of inhibition of and was maximum for triple antibiotic paste (24.74 ± 0.622 mm, 28.22 ± 0.489 mm), followed by BioPure MTAD (19.58 ± 1.734 mm, 24.75 ± 0.954 mm) and propolis (13.10 ± 0.278 mm, 17.96 ± 0.163 mm). Similarly, the mean zone of inhibition of and was maximum for triple antibiotic paste (26.86 ± 0.112 mm, 32.10 ± 0.908 mm), followed by BioPure MTAD (20.13 ± 1.842 mm, 27.22 ± 1.977) and propolis (14.11 ± 0.101 mm, 19.90 ± 0.742 mm) after 7 days. Statistically significant differences ( <0.0001) were found between the groups.

CONCLUSION

Present study concluded that the antimicrobial effectiveness of triple antibiotic paste was significantly more than BioPure MTAD and propolis against and at the end of 2nd and 7th day.

CLINICAL SIGNIFICANCE

An endodontic treatment is considered successful only when the root canals are completely eradicated of microorganisms. As the morphology of the root canals is complex, mechanical instrumentation alone cannot completely debride them. Thus, the role of intracanal medicaments in complementing the mechanical instrumentation becomes important.

摘要

目的

本研究的目的是比较各种根管内药物对粪肠球菌和白色念珠菌的抗菌效果。材料和方法：本研究纳入60颗单根、无龋、无发育缺陷且此前因正畸目的而拔除的恒牙下颌前磨牙。粪肠球菌和白色念珠菌菌株分别在脑心浸液（BHI）和沙氏葡萄糖（SD）琼脂平板上培养。60个标本分为两个主要组和三个亚组，每组10颗牙接受一种药物；第一组：（亚组Ia：BioPure MTAD，亚组Ib：蜂胶，亚组Ic：三联抗生素糊剂），第二组：（亚组IIa：BioPure MTAD，亚组IIb：蜂胶，亚组IIc：三联抗生素糊剂）。在第2天和第7天结束时评估根管内药物对粪肠球菌和白色念珠菌的抗菌活性。用单因素方差分析检验分析平均抑菌圈。

结果

2天后，三联抗生素糊剂对粪肠球菌和白色念珠菌的平均抑菌圈最大（分别为24.74±0.622mm，28.22±0.489mm），其次是BioPure MTAD（分别为19.58±1.734mm，24.75±0.954mm）和蜂胶（分别为13.10±0.278mm，17.96±0.163mm）。同样，7天后，三联抗生素糊剂对粪肠球菌和白色念珠菌的平均抑菌圈最大（分别为26.86±0.112mm，32.10±0.908mm），其次是BioPure MTAD（分别为20.13±1.842mm，27.22±1.977mm）和蜂胶（分别为14.11±0.101mm，19.90±0.742mm）。组间差异有统计学意义（P<0.0001）。