Jarrell J, Lai E V, Barr R, McMahon A, Belbeck L, O'Connell G
Cancer Res. 1987 May 1;47(9):2340-3.
The effects of radiation and chemotherapy on gonadal function are relevant to the morbidity induced by such treatments. Cyclophosphamide given i.p. to rats on Day 30 of age delayed vaginal opening, prevented vaginal cyclicity, and caused a reduction in serum estradiol and progesterone. Antral follicular atresia increased in a dose-dependent fashion in response to cyclophosphamide (0 mg/kg, 53.5%; 1 mg/kg, 67.3%; 50 mg/kg, 65.7%; 100 mg/kg, 73.9%; 150 mg/kg, 92.2%). Despite such alterations in ovarian function, serum gonadotrophins did not rise. The concurrent administration of 0, 20, 30, 40, 50, and 60 Gy of radiation to the exteriorized ovaries in rats receiving 50 mg/kg cyclophosphamide induced widespread loss of primordial, preantral, and healthy antral follicles associated with reduction in serum progesterone and estradiol. Such irradiation induced dose-related increases in serum follicle-stimulating hormone and luteinizing hormone. Parenteral cyclophosphamide and local irradiation appear to induce ovarian toxicity by different mechanisms.
放疗和化疗对性腺功能的影响与这些治疗所引发的发病率相关。在30日龄大鼠腹腔注射环磷酰胺会延迟阴道开口，阻止阴道周期性变化，并导致血清雌二醇和孕酮水平降低。随着环磷酰胺剂量增加（0 mg/kg，53.5%；1 mg/kg，67.3%；50 mg/kg，65.7%；100 mg/kg，73.9%；150 mg/kg，92.2%），窦状卵泡闭锁呈剂量依赖性增加。尽管卵巢功能出现了这些变化，但血清促性腺激素并未升高。在接受50 mg/kg环磷酰胺的大鼠中，对其外露卵巢同时给予0、20、30、40、50和60 Gy的辐射，会导致原始卵泡、窦前卵泡和健康窦状卵泡广泛丢失，同时血清孕酮和雌二醇水平降低。这种辐射会导致血清促卵泡生成素和促黄体生成素呈剂量相关增加。腹腔注射环磷酰胺和局部辐射似乎通过不同机制诱导卵巢毒性。
