Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK.
Walgreens Boots Alliance, Thane Road, Nottingham NG90 1BS, UK.
Eur J Pharm Biopharm. 2019 Jul;140:121-140. doi: 10.1016/j.ejpb.2019.05.001. Epub 2019 May 3.
Since the first patent for microneedles was filed in the 1970s, research on utilising microneedles as a drug delivery system has progressed significantly. In addition to the extensive research on microneedles for improving transdermal drug delivery, there is a growing interest in using these devices to manage dermatological conditions. This review aims to provide the background on microneedles, the clinical benefits, and challenges of the device along with the potential dermatological conditions that may benefit from the application of such a drug delivery system. The first part of the review provides an outline on benefits and challenges of translating microneedle-based drug delivery systems into clinical practice. The second part of the review covers the application of microneedles in treating dermatological conditions. The efficacy of microneedles along with the limitations of such a strategy to treat diseased skin shall be addressed.
自 20 世纪 70 年代首例微针专利申请以来，人们对微针作为药物传递系统的研究取得了显著进展。除了广泛研究微针对改善经皮药物传递的作用外，人们越来越关注利用这些装置来治疗皮肤病。本综述旨在提供微针的背景信息、该设备的临床益处和挑战，以及可能受益于这种药物传递系统应用的潜在皮肤病。综述的第一部分概述了将基于微针的药物传递系统转化为临床实践的益处和挑战。综述的第二部分涵盖了微针在治疗皮肤病方面的应用。将讨论微针的疗效以及这种治疗病态皮肤策略的局限性。
