Browning J L, Ribolini A
J Immunol. 1987 May 1;138(9):2857-63.
We have studied the short-term effects of interleukin 1, lipopolysaccharide, and interferon on prostaglandin release from freshly isolated human peripheral monocytes. When the cells were pretreated for 8 to 9 hr with either E. coli lipopolysaccharide or recombinant interleukin 1 (beta), prostaglandin release increased. Inclusion of recombinant IFN-alpha or IFN-gamma during the pretreatment phase blocked subsequent prostaglandin release. Interferons were effective at concentrations in the range of 1 to 10 antiviral units/ml, and the inhibition was manifested within several hours after exposure to the lymphokine. Similar trends were observed by measuring thromboxane release. These data suggest antagonistic roles for interleukin 1 and interferon in the regulation of eicosanoid release from monocytes.
我们研究了白细胞介素1、脂多糖和干扰素对新鲜分离的人外周血单核细胞释放前列腺素的短期影响。当细胞用大肠杆菌脂多糖或重组白细胞介素1（β）预处理8至9小时时，前列腺素释放增加。在预处理阶段加入重组干扰素α或干扰素γ可阻断随后的前列腺素释放。干扰素在1至10抗病毒单位/毫升的浓度范围内有效，并且在接触淋巴因子后数小时内即可表现出抑制作用。通过测量血栓素释放也观察到了类似的趋势。这些数据表明白细胞介素1和干扰素在调节单核细胞类花生酸释放中具有拮抗作用。
