Department of Orthopaedic Surgery, The Second Affiliated Hospital of Nanchang University, NanChang, 330006, P.R. China.
Biomater Sci. 2019 Jun 25;7(7):2826-2832. doi: 10.1039/c9bm00082h.
Implant infections frequently occur in various kinds of surgery. Apart from antibiotics, the surface modification of implant material is a promising avenue to resolve this global problem. An ideal implant interface is expected to possess good biocompatibility, as well as broad-spectrum and long-term bacterial inhibition capabilities. Here, a delicate cicada and catkin inspired dual biomimetic structure was proposed, for the first time, to improve the antibacterial properties of implant material. By using poly(ether-ether-ketone) (PEEK) as a model implant, the relative in vitro and in vivo evaluations demonstrated that this dual biomimetic structure could simultaneously provide less bacterial adhesion, wider antimicrobial range and longer antibacterial durability. Meanwhile, the modified implant also retained ideal biocompatibility. Most importantly, the relative dual biomimetic structure engineering process could be accomplished through a simple, economic and fast hydrothermal chemical reaction, which might have an impact on the development of future biomedical materials.
植入物感染经常发生在各种外科手术中。除了抗生素，植入材料的表面改性是解决这一全球性问题的一个有前途的途径。理想的植入物界面应具有良好的生物相容性以及广谱和长期的细菌抑制能力。在这里，首次提出了一种精致的蝉和柳絮启发的双重仿生结构，以提高植入物材料的抗菌性能。通过使用聚醚醚酮（PEEK）作为模型植入物，相对的体外和体内评估表明，这种双重仿生结构可以同时提供更少的细菌附着、更宽的抗菌范围和更长的抗菌耐久性。同时，改性植入物也保留了理想的生物相容性。最重要的是，相对的双重仿生结构工程过程可以通过简单、经济和快速的水热化学反应来完成，这可能对未来生物医学材料的发展产生影响。
