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一种高选择性含镧探针,用于炭疽生物标志物的比率型荧光检测。

A highly selective lanthanide-containing probe for ratiometric luminescence detection of an anthrax biomarker.

机构信息

School of Chemical Engineering and Technology, Hebei University of Technology, GuangRong Dao 8, Hongqiao District, Tianjin 300130, P. R. China.

出版信息

Dalton Trans. 2019 Jun 14;48(22):7714-7719. doi: 10.1039/c9dt01477b. Epub 2019 May 8.

DOI:10.1039/c9dt01477b
PMID:31065665
Abstract

Since anthrax spores are highly lethal to human beings and animals, and also potential biological warfare agents, it is highly desirable to develop simple, robust and easy-device sensors that are rapid and sensitive, and can selectively detect the Bacillus anthrax biomarker dipicolinic acid (DPA) quantitatively. Herein, we report a ratiometric luminescent "turn-on" sensor via mixing Eu ions, sodium polyacrylate and internal luminescence reference in water, which can identify the Bacillus anthrax biomarker dipicolinic acid (DPA) quantitatively with outstanding selectivity over aromatic ligands and amino acids, even including all of the 5 DPA isomers.

摘要

由于炭疽芽孢对人类和动物具有高度致命性,并且也是潜在的生物战剂,因此非常希望开发出简单、稳健且易于使用的设备传感器,这些传感器能够快速、灵敏且选择性地定量检测炭疽芽孢杆菌生物标志物吡咯烷二羧酸(DPA)。在此,我们报告了一种通过在水中混合 Eu 离子、聚丙烯酸钠和内部发光基准物的比率型发光“开启”传感器,该传感器可以对炭疽芽孢杆菌生物标志物吡咯烷二羧酸(DPA)进行定量识别,对芳香族配体和氨基酸具有出色的选择性,甚至包括所有 5 种 DPA 异构体。

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