伴有和不伴有抗视网膜抗体的原田病患者临床特征的比较。
Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies.
作者信息
Hashimoto Yuki, Saito Wataru, Namba Kenichi, Mizuuchi Kazuomi, Iwata Daiju, Noda Kousuke, Kanda Atsuhiro, Ishida Susumu
机构信息
Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan.
Kaimeido Eye and Dental Clinic, Sapporo, Japan.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2019 Aug;257(8):1751-1758. doi: 10.1007/s00417-019-04330-1. Epub 2019 May 7.
PURPOSE
To compare the clinical characteristics of Vogt-Koyanagi-Harada (VKH) disease patients with and without anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy.
METHODS
Using immunoblot analyses, serum autoantibodies for recoverin, carbonic anhydrase II, and α-enolase were examined in 20 treatment-naïve patients with VKH disease. Clinical factors before and after systemic corticosteroid therapy, including best-corrected visual acuity (BCVA) and macular outer retinal morphology, were statistically compared between patients with VKH disease with and without ARAs.
RESULTS
Serum ARAs were detected in 50.0% of patients with VKH disease. There were no significant differences in clinical factors between the two groups, including final BCVA, frequency of uveitis recurrence, and recovery of the macular ellipsoid zone after systemic corticosteroid therapy.
CONCLUSIONS
Our results suggest that the detected ARAs did not influence visual outcomes, the chronicity of uveitis, or outer retinal morphology in patients with VKH disease.
目的
比较伴有和不伴有自身免疫性视网膜病中常见的抗视网膜抗体（ARA）的葡萄膜大脑炎（VKH）病患者的临床特征。
方法
采用免疫印迹分析，对20例初治的VKH病患者检测血清中恢复蛋白、碳酸酐酶II和α-烯醇化酶的自身抗体。对伴有和不伴有ARA的VKH病患者全身糖皮质激素治疗前后的临床因素，包括最佳矫正视力（BCVA）和黄斑外视网膜形态进行统计学比较。
结果
50.0%的VKH病患者检测到血清ARA。两组之间的临床因素无显著差异，包括最终BCVA、葡萄膜炎复发频率和全身糖皮质激素治疗后黄斑椭圆体带的恢复情况。
结论
我们的结果表明，检测到的ARA对VKH病患者的视力预后、葡萄膜炎的慢性病程或外视网膜形态没有影响。
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