Ten Berge Josianne C E M, Schreurs Marco W J, Vermeer Jacolien, Meester-Smoor Magda A, Rothova Aniki
Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.
Acta Ophthalmol. 2016 May;94(3):282-8. doi: 10.1111/aos.12939. Epub 2016 Jan 8.
To determine the prevalence of serum antiretinal antibodies (ARAs) among patients with uveitis and establish their clinical relevance.
This prospective study assessed the presence of ARAs by indirect immunofluorescence (IIF) using primate retina in 126 patients with uveitis and 60 healthy controls. Clinical data of uveitis patients were collected from medical charts and included the classification of uveitis, cause of uveitis or its association with systemic disease, stage and activity of uveitis and specific retinal features. Correlations between the presence of specific ARAs and various clinical characteristics were analysed.
The presence of ARAs was observed in 49 of 104 (47%) of patients with uveitis and in 10 of 59 (17%) of healthy controls (p < 0.001). Staining of the nuclear layers or the photoreceptors were both more often observed in patients with uveitis compared to healthy controls (p = 0.002 and p = 0.018, respectively). No specific associations were found between the presence of serum ARAs and various clinical characteristics.
Serum ARAs were more frequent in patients with uveitis compared to healthy controls, but their clinical role remains elusive. The assessment of intraocular production of specific ARAs may provide further insight into the role of ocular autoantibodies in diverse uveitis entities.
确定葡萄膜炎患者血清抗视网膜抗体（ARA）的患病率，并确定其临床相关性。
这项前瞻性研究通过间接免疫荧光法（IIF），使用灵长类动物视网膜，对126例葡萄膜炎患者和60例健康对照者进行ARA检测。从病历中收集葡萄膜炎患者的临床数据，包括葡萄膜炎的分类、葡萄膜炎的病因或其与全身性疾病的关联、葡萄膜炎的分期和活动度以及特定的视网膜特征。分析特定ARA的存在与各种临床特征之间的相关性。
104例葡萄膜炎患者中有49例（47%）检测到ARA，59例健康对照者中有10例（17%）检测到ARA（p<0.001）。与健康对照者相比，葡萄膜炎患者中核层或光感受器的染色更为常见（分别为p=0.002和p=0.018）。血清ARA的存在与各种临床特征之间未发现特定关联。
与健康对照者相比，葡萄膜炎患者血清ARA更为常见，但其临床作用仍不明确。评估特定ARA的眼内产生情况可能会进一步深入了解眼内自身抗体在不同葡萄膜炎类型中的作用。
