输精管切除术的免疫学后果：I. 输精管切除术后一年的前瞻性研究。
Immunological consequences of vasectomy: I. Prospective study through one-year postvasecotomy.
作者信息
Lucas P L, Rose N R
出版信息
Arch Androl. 1978 May;1(3):249-55. doi: 10.3109/01485017808988344.
Autoimmunity to sperm developed in two-thirds of men within 1 year after vasectomy as measured by sperm agglutinating and sperm immobilizing antibody tests. Sperm antibody responses to vasectomy were greater in younger than in older men. A direct relationship was apparent between increasing incidence of sperm immobilizing antibody and genetic predisposition to autoimmune disease. Some vasectomized men developed immune responses to autoantigens other than spermatozoa. Increased antithyroglobulin activity was evenly divided between patients who formed sperm antibody and those who did not. Antinuclear activity was more frequent in patients who were sperm antibody responders.
通过精子凝集和精子制动抗体检测发现，三分之二的男性在输精管结扎术后1年内会产生精子自身免疫。年轻男性对输精管结扎术的精子抗体反应比年长男性更强烈。精子制动抗体发病率的增加与自身免疫性疾病的遗传易感性之间存在明显的直接关系。一些输精管结扎的男性对精子以外的自身抗原产生了免疫反应。形成精子抗体的患者和未形成精子抗体的患者中抗甲状腺球蛋白活性增加的情况分布均匀。精子抗体反应阳性的患者中抗核活性更为常见。
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