Department of Family Medicine, CHA Bundang Medical Center, CHA University, Seongnam, 13496, Republic of Korea.
Department of Clinical Pharmacology and Therapeutics, CHA Bundang Medical Center, CHA University, Seongnam, 13496, Republic of Korea.
Sci Rep. 2019 May 8;9(1):7080. doi: 10.1038/s41598-019-43598-5.
Although colonoscopy is commonly conducted for medical check-ups in Korea, investigations for the influence of bowel preparation on various health conditions are insufficient. This cross-sectional study investigated whether bowel preparation has an influence on serum levels of testosterone. A total of 1114 men were divided into the bowel preparation group and control groups. The median total and free testosterone levels were significantly lower in the bowel preparation group (14.89 and 0.26 nmol/L, respectively) than in the control groups (15.72 and 0.28 nmol/L, respectively). The level of total testosterone significantly increased with age in the bowel preparation group (r = 0.103). The differences in the levels of total and free testosterone between the 2 groups were more prominent in younger men than in older men. In multivariate regression models, bowel preparation was independently associated with the levels of total and free testosterone. In these models, the interaction between age and bowel preparation was significant for the levels of total and free testosterone. In conclusion, bowel preparation may independently decrease the serum levels of total and free testosterone. The decline in testosterone was more evident in younger men than in older men.
虽然结肠镜检查在韩国通常用于体检，但对肠道准备对各种健康状况影响的研究还不够充分。本横断面研究调查了肠道准备是否会影响血清睾酮水平。共有 1114 名男性被分为肠道准备组和对照组。肠道准备组的总睾酮和游离睾酮中位数水平明显低于对照组（分别为 14.89 和 0.26 nmol/L）（分别为 15.72 和 0.28 nmol/L）。肠道准备组的总睾酮水平随年龄增长呈显著上升趋势（r=0.103）。在年轻男性中，两组间总睾酮和游离睾酮水平的差异比老年男性更为显著。在多变量回归模型中，肠道准备与总睾酮和游离睾酮水平独立相关。在这些模型中，年龄和肠道准备之间的相互作用对总睾酮和游离睾酮水平有显著影响。总之，肠道准备可能会独立降低血清总睾酮和游离睾酮水平。睾酮的下降在年轻男性中比在老年男性中更为明显。
