Lichtenstein G R, Cohen L B, Uribarri J
Hospital of the University of Pennsylvania, Gastroenterology Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA.
Aliment Pharmacol Ther. 2007 Sep 1;26(5):633-41. doi: 10.1111/j.1365-2036.2007.03406.x.
Patient compliance with screening recommendations for colorectal cancer remains low, despite a 90% survival rate achieved with early detection. Bowel preparation is a major deterrent for patients undergoing screening colonoscopy. More than half of patients taking polyethylene glycol electrolyte lavage solution and sodium phosphate preparations experience adverse events, such as nausea and abdominal pain. Many adverse events may be associated with dehydration, including rare reports of renal toxicity in patients taking sodium phosphate products. Addressing dehydration-related safety issues through patient screening and education may improve acceptance of bowel preparations, promote compliance and increase the likelihood of a successful procedure.
To evidence safety issues associated with bowel preparation are generally related to inadequate hydration.
Dehydration-related complications may be avoided through proper patient screening, for example, renal function and comorbid conditions should be considered when choosing an appropriate bowel preparation. In addition, patient education regarding the importance of maintaining adequate hydration before, during and after bowel preparation may promote compliance with fluid volume recommendations and reduce the risk of dehydration-related adverse events.
Proper patient screening and rigorous attention by patients and healthcare providers to hydration during bowel preparation may provide a safer, more effective screening colonoscopy.
尽管早期检测可使结直肠癌患者的生存率达到90%,但患者对结直肠癌筛查建议的依从性仍然很低。肠道准备是接受结肠镜筛查患者的主要阻碍因素。超过半数服用聚乙二醇电解质灌洗液和磷酸钠制剂的患者会出现恶心、腹痛等不良事件。许多不良事件可能与脱水有关,包括服用磷酸钠产品的患者出现肾毒性的罕见报告。通过患者筛查和教育解决与脱水相关的安全问题,可能会提高患者对肠道准备的接受度,促进依从性,并增加检查成功的可能性。
证明与肠道准备相关的安全问题通常与水合作用不足有关。
通过适当的患者筛查可以避免与脱水相关的并发症,例如,在选择合适的肠道准备方法时应考虑肾功能和合并症。此外,对患者进行关于在肠道准备前、中、后保持充足水合作用重要性的教育,可能会促进患者遵守液体量建议,并降低与脱水相关不良事件的风险。
适当的患者筛查以及患者和医护人员在肠道准备期间对水合作用的严格关注,可能会提供更安全、更有效的结肠镜筛查。