铱（III）催化吡唑烷酮与丙炔酸酯的环化反应：一种简便合成吡唑并[1,2-a]吲唑的方法。
Iridium(iii)-catalysed annulation of pyrazolidinones with propiolates: a facile route to pyrazolo[1,2-a] indazoles.
作者信息
Yang Zi, Song Zhenyu, Jie Lianghua, Wang Lianhui, Cui Xiuling
机构信息
Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, P. R. China.
出版信息
Chem Commun (Camb). 2019 May 28;55(43):6094-6097. doi: 10.1039/c9cc02232e. Epub 2019 May 9.
A facile synthesis of various pyrazolo[1,2-a] indazoles from pyrazolidinones and propiolates via iridium(iii)-catalysed C-H bond activation/subsequent [4+1] cyclization has been developed. The reaction proceeds smoothly under mild reaction conditions and propiolates act as a novel C synthon. This transformation represents a redox-neutral process, exhibits a highly regioselectivity, and tolerates various functional groups.
通过铱（III）催化的C-H键活化/随后的[4+1]环化反应，从吡唑烷酮和丙炔酸酯轻松合成各种吡唑并[1,2-a]吲唑的方法已经开发出来。该反应在温和的反应条件下顺利进行，丙炔酸酯作为一种新型的C合成子。这种转化代表了一种氧化还原中性过程，具有高度的区域选择性，并且能够耐受各种官能团。
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