Kaneko Y, Rowley J D, Check I, Variakojis D, Moohr J W
Blood. 1980 Nov;56(5):782-5.
A child who had acute lymphoblastic leukemia (ALL) associated with an 8;14 chromosome translocation and with a pre-B phenotype is described. The leukemic cells were determined to be pre-B-cells on the basis of intracytoplasmic mu-chain immunoglobulin (cIgM+) and the common-ALL antigen, lack of receptors for sheep erythrocytes, and lack of surface immunoglobulin. The 8;14 translocation is frequently found in patients with Burkitt's lymphoma and in most patients with B-cell ALL and is known to carry a poor prognosis. Thus far, no karyotypes have been reported for patients with pre-B-ALL. The present case indicates that a 14q+ chromosome may provide a proliferative advantage not only to cells with a B-cell phenotype, but also to pre-B-cells. The short survival of our patient also suggests that the 14q+ abnormality and the pre-B phenotype may signal a poor prognosis.
本文描述了一名患有急性淋巴细胞白血病（ALL）的儿童，该白血病与8;14染色体易位及前B表型相关。根据胞质内μ链免疫球蛋白（cIgM+）和常见ALL抗原、缺乏绵羊红细胞受体以及缺乏表面免疫球蛋白，确定白血病细胞为前B细胞。8;14易位常见于伯基特淋巴瘤患者及大多数B细胞ALL患者，且已知预后不良。迄今为止，尚未有前B-ALL患者的核型报告。本病例表明，14q+染色体不仅可能为具有B细胞表型的细胞，也为前B细胞提供增殖优势。我们患者的短期生存也提示14q+异常和前B表型可能预示预后不良。
