Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.
Molecules. 2021 Feb 21;26(4):1145. doi: 10.3390/molecules26041145.
With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.
随着全球工业的飞速发展和产品流通日益频繁，手性药物/农药的分离与检测变得愈发重要。物质的手性会对人体造成危害，药物对映体的选择性内分泌干扰效应是由其与受体的不同的对映体特异性结合引起的。本文综述了色谱法和基于膜的对映体分离技术对手性分子的特异性识别和拆分。详细介绍了基于手性固定相（CSP）柱的色谱对映体分离和基于膜的对映体过滤。此外，还总结了这些手性拆分方法在化学、环境、生物、医学和食品工业中的实际应用的独特性质。我们进一步讨论了分析对映体分离中的识别机制，并分析了色谱法和基于膜的对映体分离的最新进展和未来前景。
