非连锁蛋白基因座之间的非随机等位基因关联：免疫球蛋白恒定区的多态性具有适应性吗？
Nonrandom allele associations between unlinked protein loci: are the polymorphisms of the immunoglobulin constant regions adaptive?
作者信息
van der Loo W, Arthur C P, Richardson B J, Wallage-Drees M, Hamers R
出版信息
Proc Natl Acad Sci U S A. 1987 May;84(9):3075-9. doi: 10.1073/pnas.84.9.3075.
Abstract
Consistent linkage disequilibrium was observed between independently segregating protein loci. In natural populations of the European rabbit Oryctolagus cuniculus, highly significant, nonrandom associations between alleles of the constant regions of the immunoglobulin light and heavy chains were found, both within localities and between localities. We suggest that the population genetic data presented here are relevant to the adaptive significance of the genetic polymorphisms of the antibody constant regions.
摘要
在独立分离的蛋白质基因座之间观察到了一致的连锁不平衡。在欧洲兔穴兔的自然种群中，在局部地区内以及不同局部地区之间，均发现免疫球蛋白轻链和重链恒定区等位基因之间存在高度显著的非随机关联。我们认为，此处呈现的群体遗传数据与抗体恒定区遗传多态性的适应性意义相关。
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The sequences of rabbit kappa light chains of b4 and b5 allotypes differ more in their constant regions than in their 3' untranslated regions.b4和b5同种异型的兔κ轻链序列在其恒定区的差异比在其3'非翻译区的差异更大。
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