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Nonrandom allele associations between unlinked protein loci: are the polymorphisms of the immunoglobulin constant regions adaptive?非连锁蛋白基因座之间的非随机等位基因关联：免疫球蛋白恒定区的多态性具有适应性吗？
Proc Natl Acad Sci U S A. 1987 May;84(9):3075-9. doi: 10.1073/pnas.84.9.3075.
2
Linkage relationship between variable and constant region allotypic determinants of human immunoglobulin heavy chains.人免疫球蛋白重链可变区与恒定区同种异型决定簇之间的连锁关系。
Nature. 1980 Jul 24;286(5771):406-7. doi: 10.1038/286406a0.
3
Allotypic markers.同种异型标记
Monogr Allergy. 1986;19:40-51.
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Serologic and molecular genetic studies of rabbit Ig heavy chains: evidence for additional C alpha and C gamma genes.兔免疫球蛋白重链的血清学和分子遗传学研究：额外的Cα和Cγ基因的证据。
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The sequences of rabbit kappa light chains of b4 and b5 allotypes differ more in their constant regions than in their 3' untranslated regions.b4和b5同种异型的兔κ轻链序列在其恒定区的差异比在其3'非翻译区的差异更大。
Nucleic Acids Res. 1983 Oct 25;11(20):7205-14. doi: 10.1093/nar/11.20.7205.
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Evidence for contrasting modes of selection at interacting globin genes in the European rabbit (Oryctolagus cuniculus).欧洲野兔（穴兔）中相互作用的珠蛋白基因的对比选择模式的证据。
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8
Estimation of gene diversity at the b locus of the constant region of the immunoglobulin light chain in natural populations of European rabbit (Oryctolagus cuniculus) in Portugal, Andalusia and on the Azorean Islands.葡萄牙、安达卢西亚及亚速尔群岛欧洲野兔（穴兔）自然种群中免疫球蛋白轻链恒定区b位点基因多样性的估计
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Testing Hypotheses about Linkage Disequilibrium with Multiple Alleles.检验多等位基因连锁不平衡假设。
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2
Linkage disequilibrium due to random genetic drift in finite subdivided populations.有限分裂群体中随机遗传漂变导致的连锁不平衡。
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Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.兔血清蛋白的同种异型。I. 免疫化学分析确定七种主要同种异型的个体差异
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Selection of viability at loci controlling protein polymorphisms in Drosophila melanogaster is very weak at most.在果蝇中，控制蛋白质多态性的基因座上的生存力选择大多非常微弱。
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9
A genomic gene encoding the b5 rabbit immunoglobulin kappa constant region: implications for latent allotype phenomenon.一种编码兔免疫球蛋白κ轻链恒定区b5的基因组基因：对潜在同种异型现象的影响。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1789-93. doi: 10.1073/pnas.81.6.1789.
10
The sequences of rabbit kappa light chains of b4 and b5 allotypes differ more in their constant regions than in their 3' untranslated regions.b4和b5同种异型的兔κ轻链序列在其恒定区的差异比在其3'非翻译区的差异更大。
Nucleic Acids Res. 1983 Oct 25;11(20):7205-14. doi: 10.1093/nar/11.20.7205.

非连锁蛋白基因座之间的非随机等位基因关联：免疫球蛋白恒定区的多态性具有适应性吗？

Nonrandom allele associations between unlinked protein loci: are the polymorphisms of the immunoglobulin constant regions adaptive?

作者信息

van der Loo W, Arthur C P, Richardson B J, Wallage-Drees M, Hamers R

出版信息

Proc Natl Acad Sci U S A. 1987 May;84(9):3075-9. doi: 10.1073/pnas.84.9.3075.

DOI:10.1073/pnas.84.9.3075
PMID:3106983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC304806/
Abstract

Consistent linkage disequilibrium was observed between independently segregating protein loci. In natural populations of the European rabbit Oryctolagus cuniculus, highly significant, nonrandom associations between alleles of the constant regions of the immunoglobulin light and heavy chains were found, both within localities and between localities. We suggest that the population genetic data presented here are relevant to the adaptive significance of the genetic polymorphisms of the antibody constant regions.

摘要

在独立分离的蛋白质基因座之间观察到了一致的连锁不平衡。在欧洲兔穴兔的自然种群中，在局部地区内以及不同局部地区之间，均发现免疫球蛋白轻链和重链恒定区等位基因之间存在高度显著的非随机关联。我们认为，此处呈现的群体遗传数据与抗体恒定区遗传多态性的适应性意义相关。