κ转基因小鼠中内源性免疫球蛋白基因重排的等位基因排斥与调控
Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
作者信息
Ritchie K A, Brinster R L, Storb U
出版信息
Nature. 1984;312(5994):517-20. doi: 10.1038/312517a0.
DOI:10.1038/312517a0
PMID:6438533
Abstract
Hybridomas were produced from spleen cells of kappa transgenic mice to investigate expression of the transgenic kappa gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. Our results show that the transgene is expressed normally and that the production of a complete immunoglobulin molecule turns off light-chain gene rearrangement.
摘要
从κ转基因小鼠的脾细胞中制备杂交瘤，以研究转基因κ基因的表达、其对等位排斥的影响以及其对轻链基因重排和表达控制的影响。我们的结果表明，转基因正常表达，完整免疫球蛋白分子的产生会关闭轻链基因重排。
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