b4和b5同种异型的兔κ轻链序列在其恒定区的差异比在其3'非翻译区的差异更大。
The sequences of rabbit kappa light chains of b4 and b5 allotypes differ more in their constant regions than in their 3' untranslated regions.
作者信息
Bernstein K E, Skurla R M, Mage R G
出版信息
Nucleic Acids Res. 1983 Oct 25;11(20):7205-14. doi: 10.1093/nar/11.20.7205.
Abstract
We report the sequence of a cDNA clone encoding the entire variable and constant regions of a rabbit kappa light chain of b5 allotype. The deduced amino acid sequence of the variable region (positions 1-95) is 86% homologous to that of a b4 light chain protein [BS-1) (1) but the b4 and b5 constant regions are only 74% homologous. Comparison of this DNA sequence to that of a cDNA clone encoding a b4 constant region shows that the kappa allotypes b4 and b5 have diverged significantly more in their coding region than in the 3' untranslated regions (86% vs 96% nucleotide sequence homologies). This implies either a function for the 3' untranslated region with evolutionary pressures to conserve or an accelerated divergence of the coding regions.
摘要
我们报道了一个编码b5同种异型兔κ轻链完整可变区和恒定区的cDNA克隆序列。可变区（第1 - 95位）推导的氨基酸序列与b4轻链蛋白[BS - 1] (1)的序列有86%的同源性，但b4和b5的恒定区同源性仅为74%。将该DNA序列与编码b4恒定区的cDNA克隆序列进行比较，结果表明κ同种异型b4和b5在编码区的差异明显大于3'非翻译区（核苷酸序列同源性分别为86%和96%）。这意味着要么3'非翻译区具有在进化压力下保守的功能，要么编码区的分化加速。
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