Faculty of Medicine and Life Sciences, Universiteit Hasselt, Hasselt, Belgium.
Department of Gastroenterology, Ziekenhuis Oost-Limburg, Genk, Belgium.
BMJ Open. 2019 May 9;9(5):e026464. doi: 10.1136/bmjopen-2018-026464.
Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) have a major impact on mortality worldwide. Although effective treatments are available for both HBV and HCV infection, <50% of the patients are even diagnosed in Belgium. This study assessed the real-life testing-and diagnosis rate by general practitioners (GPs) in Flanders, Belgium.
We assessed the testing rate for HBV and HCV in 48 primary care practices with electronic medical records linked into one central registry in Flanders, Belgium.
The registry contains data of 440 140 patients over 20 years, which corresponds to 2.2% of the total Flemish population yearly. The primary care practices are distributed across Flanders and the patient population is representative for the distribution of age, gender and socioeconomic status at the community level.
Of 440 140 patients included in the registry, 7892 (1.8%) patients were screened for hepatitis B surface antigen (HBsAg) and 7206 (1.6%) for hepatitis C antibody (HCV Ab) of whom 369 (4.7%) and 163 (2.3%) tested positive, respectively. Of 14 059 patients with chronic liver enzyme elevation, 1112 (7.9%) and 1395 (9.9%) were tested for HBsAg and HCV Ab, respectively. There was no improvement in testing rates over time.
This study demonstrates that real-life testing uptake for viral hepatitis B and C is suboptimal in the general practices in Flanders, even in patients with chronically elevated liver enzymes. As GPs play a crucial role in prevention, diagnosis and linkage to care, efforts and strategies to increase the testing uptake for HBV and HCV are urgently needed.
乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)的慢性感染对全球死亡率有重大影响。尽管有针对 HBV 和 HCV 感染的有效治疗方法,但在比利时,<50%的患者得到诊断。本研究评估了比利时佛兰德斯的全科医生(GP)的实际检测和诊断率。
我们评估了比利时佛兰德斯的 48 家初级保健机构中 HBV 和 HCV 的检测率,这些机构的电子病历与一个中央登记处相链接。
该登记处包含了 440140 名超过 20 岁患者的数据,相当于每年佛兰德斯总人口的 2.2%。初级保健机构分布在佛兰德斯各地,患者人群在社区层面代表了年龄、性别和社会经济地位的分布。
在登记处纳入的 440140 名患者中,7892 名(1.8%)患者接受了乙型肝炎表面抗原(HBsAg)筛查,7206 名(1.6%)接受了丙型肝炎抗体(HCV Ab)筛查,其中 369 名(4.7%)和 163 名(2.3%)检测结果阳性。在 14059 名慢性肝酶升高的患者中,分别有 1112 名(7.9%)和 1395 名(9.9%)接受了 HBsAg 和 HCV Ab 检测。随着时间的推移,检测率并没有提高。
本研究表明,在佛兰德斯的全科实践中,HBV 和 HCV 的实际检测率不理想,即使是慢性肝酶升高的患者也是如此。由于全科医生在预防、诊断和联系护理方面发挥着关键作用,因此迫切需要采取努力和策略来提高 HBV 和 HCV 的检测率。