School of Materials Science and Engineering, PCFM Lab, Sun Yat-sen University, Guangzhou 510275, P. R. China.
Chem Commun (Camb). 2019 May 28;55(44):6213-6216. doi: 10.1039/c9cc02989c.
The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation of anilines with alcohols by a bis-NHC manganese complex is presented. This system was applied to a large range of alcohols and anilines, including biologically relevant motifs and challenging methanol. Experimental and computational studies suggest an outer-sphere mechanism for this NHC-Mn system.
首次提出了一种由双 NHC 锰配合物催化的室温非贵金属均相体系，实现了苯胺与醇的选择性 N-烷基化反应。该体系适用于多种醇和苯胺，包括具有生物相关结构的醇和苯胺，以及具有挑战性的甲醇。实验和计算研究表明，该 NHC-Mn 体系的反应机理为外球机理。
